Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | LUZ07_RS11375 | Genome accession | NZ_CP089476 |
| Coordinates | 2264443..2266071 (-) | Length | 542 a.a. |
| NCBI ID | WP_001186596.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain 3596_II_ST8 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2213895..2267438 | 2264443..2266071 | within | 0 |
Gene organization within MGE regions
Location: 2213895..2267438
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUZ07_RS11085 | ccrC | 2213895..2215580 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| LUZ07_RS11090 | tnpA | 2215628..2216113 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| LUZ07_RS11095 | - | 2216405..2216743 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| LUZ07_RS11100 | - | 2216837..2217148 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| LUZ07_RS11105 | - | 2217164..2217670 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| LUZ07_RS11110 | - | 2217691..2218008 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| LUZ07_RS11115 | - | 2218127..2219212 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| LUZ07_RS11120 | - | 2219209..2221101 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| LUZ07_RS11125 | - | 2221108..2221485 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| LUZ07_RS11130 | - | 2221636..2222418 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| LUZ07_RS11135 | erm(A) | 2222544..2223275 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| LUZ07_RS11140 | - | 2223333..2223392 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| LUZ07_RS11145 | - | 2223784..2224446 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| LUZ07_RS11150 | - | 2224678..2224824 (+) | 147 | Protein_2167 | JAB domain-containing protein | - |
| LUZ07_RS11155 | - | 2224994..2225866 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| LUZ07_RS11160 | - | 2225923..2226213 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| LUZ07_RS11165 | - | 2226229..2226717 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| LUZ07_RS11170 | - | 2226852..2227379 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| LUZ07_RS11175 | - | 2227441..2227857 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| LUZ07_RS11180 | - | 2228133..2228807 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| LUZ07_RS11185 | - | 2229090..2230435 (+) | 1346 | Protein_2174 | dihydrolipoyl dehydrogenase family protein | - |
| LUZ07_RS11190 | merR | 2230735..2231142 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| LUZ07_RS11195 | - | 2231159..2231512 (+) | 354 | WP_000746200.1 | TlpA disulfide reductase family protein | - |
| LUZ07_RS11200 | - | 2231509..2232189 (+) | 681 | WP_000010351.1 | cytochrome c biogenesis CcdA family protein | - |
| LUZ07_RS11205 | - | 2232324..2232662 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| LUZ07_RS11210 | merA | 2232720..2234363 (+) | 1644 | WP_000193220.1 | mercury(II) reductase | - |
| LUZ07_RS11215 | merB | 2234445..2235095 (+) | 651 | WP_000790334.1 | organomercurial lyase MerB | - |
| LUZ07_RS11220 | - | 2235290..2235820 (-) | 531 | WP_041205518.1 | hypothetical protein | - |
| LUZ07_RS11225 | - | 2235856..2236530 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| LUZ07_RS11230 | - | 2236963..2237295 (-) | 333 | WP_001803416.1 | DUF3021 domain-containing protein | - |
| LUZ07_RS11235 | - | 2237324..2237566 (-) | 243 | WP_001803415.1 | LytTR family DNA-binding domain-containing protein | - |
| LUZ07_RS11240 | - | 2237698..2238372 (-) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| LUZ07_RS11245 | tet(K) | 2238569..2239948 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| LUZ07_RS11250 | mobV | 2240134..2241375 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| LUZ07_RS11255 | - | 2241902..2242856 (+) | 955 | Protein_2188 | replication initiation factor domain-containing protein | - |
| LUZ07_RS11260 | - | 2242945..2243619 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| LUZ07_RS11265 | - | 2243703..2244044 (+) | 342 | WP_001797647.1 | hydroxymethylglutaryl-CoA synthase | - |
| LUZ07_RS11270 | - | 2244961..2245704 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| LUZ07_RS11275 | - | 2245801..2246229 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| LUZ07_RS11280 | mecA | 2246275..2248284 (-) | 2010 | WP_078056515.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| LUZ07_RS11285 | mecR1 | 2248381..2250138 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| LUZ07_RS11290 | mecI | 2250138..2250509 (+) | 372 | Protein_2195 | mecA-type methicillin resistance repressor MecI | - |
| LUZ07_RS11295 | psm-mec | 2250594..2250662 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| LUZ07_RS11300 | - | 2251021..2252130 (+) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| LUZ07_RS11305 | cstB | 2252244..2253578 (-) | 1335 | Protein_2198 | persulfide dioxygenase-sulfurtransferase CstB | - |
| LUZ07_RS11310 | - | 2253611..2254675 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| LUZ07_RS11315 | cstR | 2254811..2255071 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| LUZ07_RS11320 | - | 2255071..2255709 (+) | 639 | Protein_2201 | sulfite exporter TauE/SafE family protein | - |
| LUZ07_RS11325 | - | 2255983..2256600 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| LUZ07_RS11330 | - | 2256681..2259095 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| LUZ07_RS11335 | - | 2259088..2259453 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| LUZ07_RS11340 | - | 2259691..2260068 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| LUZ07_RS11345 | - | 2260075..2261967 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| LUZ07_RS11350 | - | 2262162..2262485 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| LUZ07_RS11355 | - | 2262478..2262684 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| LUZ07_RS11360 | - | 2262686..2263207 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| LUZ07_RS11365 | - | 2263226..2263537 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| LUZ07_RS11370 | - | 2263622..2263972 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| LUZ07_RS11375 | ccrB | 2264443..2266071 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| LUZ07_RS11380 | ccrA | 2266092..2267438 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62274.15 Da Isoelectric Point: 9.7334
>NTDB_id=637097 LUZ07_RS11375 WP_001186596.1 2264443..2266071(-) (ccrB) [Staphylococcus aureus strain 3596_II_ST8]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1629 bp
>NTDB_id=637097 LUZ07_RS11375 WP_001186596.1 2264443..2266071(-) (ccrB) [Staphylococcus aureus strain 3596_II_ST8]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
86.531 |
100 |
0.865 |