Detailed information NTG0637050

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: LUY92_RS10255
• Genome accession: NZ_CP089473
• Coordinates: 2054868..2056496 (+)
• Length: 542 a.a.
• NCBI ID: WP_001186602.1
• Uniprot ID: Q9XB94
• Organism: Staphylococcus aureus strain 0.1239_III_ST239
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2053497..2074837	2054868..2056496	within	0

Gene organization within MGE regions

Location: 2053497..2074837

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUY92_RS10250	ccrA	2053497..2054846 (+)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene
LUY92_RS10255	ccrB	2054868..2056496 (+)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
LUY92_RS10260	-	2057014..2057364 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
LUY92_RS10265	-	2057451..2057762 (+)	312	WP_000700853.1	DUF960 family protein	-
LUY92_RS10270	-	2057780..2058286 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
LUY92_RS10275	-	2058307..2058624 (+)	318	WP_000659050.1	JAB domain-containing protein	-
LUY92_RS10280	-	2058743..2059828 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
LUY92_RS10285	-	2059825..2061717 (+)	1893	WP_001557544.1	site-specific integrase	-
LUY92_RS10290	-	2061724..2062101 (+)	378	WP_000361059.1	DUF6262 family protein	-
LUY92_RS10295	-	2062252..2063034 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
LUY92_RS10300	erm(A)	2063160..2063891 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
LUY92_RS10305	-	2063949..2064008 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
LUY92_RS10310	-	2064400..2065062 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
LUY92_RS10315	-	2065407..2066045 (-)	639	Protein_1993	sulfite exporter TauE/SafE family protein	-
LUY92_RS10320	cstR	2066045..2066305 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
LUY92_RS10325	-	2066441..2067505 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
LUY92_RS10330	cstB	2067538..2068872 (+)	1335	Protein_1996	persulfide dioxygenase-sulfurtransferase CstB	-
LUY92_RS10335	-	2068986..2070095 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
LUY92_RS10340	psm-mec	2070450..2070518 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
LUY92_RS10345	mecI	2070603..2070974 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
LUY92_RS10350	mecR1	2070974..2072731 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
LUY92_RS10355	mecA	2072828..2074837 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62664.84 Da
• Isoelectric Point: 9.8600

>NTDB_id=637050 LUY92_RS10255 WP_001186602.1 2054868..2056496(+) (ccrB) [Staphylococcus aureus strain 0.1239_III_ST239]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide

• Length: 1629 bp

>NTDB_id=637050 LUY92_RS10255 WP_001186602.1 2054868..2056496(+) (ccrB) [Staphylococcus aureus strain 0.1239_III_ST239]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

• Ogr/Delta-like zinc finger (Ogr_Delta) (301-356)

• Resolvase, N terminal domain (Resolvase) (11-156)

• Recombinase (Recombinase) (180-280)

3D structure

• AlphaFold DB: Q9XB94

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	100	100	1