Detailed information NTG0637016

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LUY92_RS00465
• Genome accession: NZ_CP089473
• Coordinates: 81469..82512 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 0.1239_III_ST239
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76469..87512

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUY92_RS00435	-	76954..77064 (+)	111	WP_001790257.1	hypothetical protein	-
LUY92_RS00440	-	77093..77506 (+)	414	WP_001557448.1	hypothetical protein	-
LUY92_RS00445	-	77937..78923 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
LUY92_RS00450	map	79395..80153 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LUY92_RS00455	-	80370..80756 (+)	387	WP_001110179.1	hypothetical protein	-
LUY92_RS00460	liaF	80771..81472 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LUY92_RS00465	vraS	81469..82512 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LUY92_RS00470	vraR	82502..83131 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LUY92_RS00475	-	83244..84461 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LUY92_RS00480	-	84739..85014 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LUY92_RS00485	-	85021..85485 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LUY92_RS00490	-	85632..85832 (+)	201	WP_000180460.1	DUF1128 family protein	-
LUY92_RS00495	-	85835..87091 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=637016 LUY92_RS00465 WP_001017131.1 81469..82512(+) (vraS) [Staphylococcus aureus strain 0.1239_III_ST239]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=637016 LUY92_RS00465 WP_001017131.1 81469..82512(+) (vraS) [Staphylococcus aureus strain 0.1239_III_ST239]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1