Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB4   Type   Machinery gene
Locus tag   LUA78_RS04950 Genome accession   NZ_CP089283
Coordinates   1043866..1046229 (+) Length   787 a.a.
NCBI ID   WP_000890516.1    Uniprot ID   Q9ZN44
Organism   Helicobacter pylori strain J99 derivative isolate D1     
Function   transformation-associated type IV transport system (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1038866..1051229
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LUA78_RS04920 (LUA78_04920) groES 1038884..1039240 (-) 357 WP_000671934.1 co-chaperone GroES -
  LUA78_RS04925 (LUA78_04925) dnaG 1039528..1041207 (+) 1680 WP_000601572.1 DNA primase -
  LUA78_RS04930 (LUA78_04930) - 1041204..1042256 (+) 1053 WP_000809440.1 MnmA/TRMU family protein -
  LUA78_RS04935 (LUA78_04935) - 1042346..1043173 (+) 828 WP_001154969.1 DUF5718 family protein -
  LUA78_RS04940 (LUA78_04940) comB2 1043320..1043601 (+) 282 WP_001272691.1 TrbC/VirB2 family protein Machinery gene
  LUA78_RS04945 (LUA78_04945) comB3 1043601..1043864 (+) 264 WP_000584953.1 hypothetical protein Machinery gene
  LUA78_RS04950 (LUA78_04950) comB4 1043866..1046229 (+) 2364 WP_000890516.1 VirB4 family type IV secretion/conjugal transfer ATPase Machinery gene
  LUA78_RS04960 (LUA78_04960) - 1046538..1047878 (+) 1341 WP_001881006.1 COG3014 family protein -
  LUA78_RS04965 (LUA78_04965) cheV1 1047985..1048950 (+) 966 WP_000785489.1 chemotaxis protein CheV1 -
  LUA78_RS04970 (LUA78_04970) nspC 1048947..1050164 (+) 1218 WP_000760797.1 carboxynorspermidine decarboxylase -
  LUA78_RS04975 (LUA78_04975) lpxE 1050225..1050761 (-) 537 WP_226928969.1 lipid A 1-phosphatase LpxE -

Sequence

Protein


Download         Length: 787 a.a.        Molecular weight: 90162.56 Da        Isoelectric Point: 7.6532

>NTDB_id=636100 LUA78_RS04950 WP_000890516.1 1043866..1046229(+) (comB4) [Helicobacter pylori strain J99 derivative isolate D1]
MLEKLLSAIKQKVSNYFLGVLPKSYSMSEENNILGLYDEHFLLTKNENLVGILRLEGVSYTHLSTEQLQDLFTERQMALD
SLEKVVARLVVKRRKIDYKQSIQSDSQYLQAILNQFENKEVYENQYFLVLESTHSLHGVLEHKKKSFMHANRENFKDILS
YKAHFLQETLKSLEIQLKNYAPKLLNSKEVLNFYAEYINGFELPLKPLVGGYLSDSYIASSITFEKDYFIQESFNQKTYN
RLIGIKAYESERITSIAVGALLYQETPLDIIFSIEPMSVNKTLSFLKERAKFSMSNLVKNELLEYQELVKTKRLSMQKFA
LNVLIKAPSLEDLDAQTSLILGLLFKENLVGVIETFGLKGGYFSFFPERIHLNHRLRFLTSKALACLMVFERQNLGFKAN
SWGNSPLSVFKNLDYSPFLFNFHNQEVSHNNAKEIARVNGHTLVIGATGSGKSTLISYLMMSALKYQNMRLLAFDRMQGL
YSFTEFFKGHYHDGQSFSINPFCLEPNLQNLEFLQSFFLSMLDLAPSRDKEALEDMNAISGAIKSLYETLYPKDFSLLDF
KETLKRTSSNQLGLSLEPYLNNPLFNALNDAFNSNAFLNVINLDAITQNPKDLGLLAYYLFYKILEESRKNDSGFLVFLD
EFKSYVENDLLNTKINALITQARKANGVVVLALQDIYQLSGVKNAHSFLSNMGTLILYPQKNARELKHNFNVPLSETEIS
FLENTPLYARQVLVKNLGNGSSNMIDVSLEGLGCYLKIFNSDSSHVNKVKALQKDYPTEWREKLLKS

Nucleotide


Download         Length: 2364 bp        

>NTDB_id=636100 LUA78_RS04950 WP_000890516.1 1043866..1046229(+) (comB4) [Helicobacter pylori strain J99 derivative isolate D1]
ATGTTAGAAAAGCTTTTAAGCGCTATCAAACAAAAAGTTTCAAACTATTTTTTAGGGGTTTTGCCTAAAAGCTATTCTAT
GAGCGAAGAAAACAACATTTTAGGCTTGTATGATGAGCATTTTTTGCTCACTAAAAACGAAAACTTAGTGGGCATCCTCC
GTTTAGAGGGGGTTAGCTACACCCATTTAAGCACAGAGCAATTGCAAGATCTTTTCACTGAGCGCCAAATGGCGTTAGAT
TCTTTAGAAAAAGTCGTGGCGCGTCTTGTGGTTAAAAGGCGTAAAATTGATTATAAACAAAGCATTCAATCTGACTCTCA
ATACTTGCAAGCGATCTTGAATCAGTTTGAAAATAAAGAAGTGTATGAGAATCAGTATTTTTTAGTTTTAGAAAGCACTC
ACTCTTTGCATGGCGTTTTGGAGCATAAGAAAAAATCTTTCATGCACGCTAATAGAGAAAATTTTAAGGATATTCTCTCT
TATAAAGCGCATTTTTTGCAAGAAACTTTAAAAAGCTTAGAAATCCAGCTCAAAAACTATGCCCCCAAACTCTTAAACTC
TAAAGAGGTTTTGAATTTTTATGCAGAATATATTAATGGGTTTGAACTCCCTTTAAAACCCCTAGTAGGGGGGTATTTGA
GCGATAGCTATATCGCTAGTTCTATCACTTTTGAAAAAGATTATTTCATTCAAGAAAGCTTTAATCAAAAAACCTATAAC
CGCTTGATTGGCATTAAAGCTTATGAGAGCGAAAGGATCACTTCTATAGCGGTGGGAGCGCTTTTATACCAAGAGACGCC
TTTGGATATTATCTTTTCCATAGAGCCTATGAGCGTCAATAAAACGCTGAGTTTTTTAAAAGAGAGGGCCAAGTTTAGCA
TGTCTAATCTTGTTAAAAACGAGCTATTAGAATACCAAGAATTAGTCAAAACCAAACGATTATCCATGCAAAAATTCGCC
CTAAACGTTCTTATCAAAGCCCCCAGTTTGGAGGATTTAGACGCTCAAACCAGCTTAATTTTAGGGCTTTTATTTAAAGA
AAACTTAGTGGGCGTTATAGAAACTTTTGGCTTGAAAGGGGGGTATTTTTCCTTTTTCCCTGAACGCATCCATTTAAACC
ACCGCTTGCGTTTTTTAACCTCTAAAGCCCTAGCGTGTTTGATGGTGTTTGAAAGGCAAAATTTAGGTTTTAAGGCTAAT
TCATGGGGGAATAGCCCTTTGAGCGTGTTTAAAAATTTGGATTATTCCCCTTTTTTATTCAATTTCCACAACCAAGAAGT
GAGCCATAATAACGCTAAAGAAATTGCCAGAGTGAATGGGCATACTTTAGTTATAGGGGCAACCGGAAGCGGTAAAAGCA
CGCTGATTAGCTATTTAATGATGAGCGCTTTAAAATACCAAAACATGCGCCTTTTAGCTTTTGACAGGATGCAAGGGTTG
TATTCTTTCACCGAATTTTTTAAAGGGCATTACCATGACGGCCAATCTTTTAGTATCAACCCCTTTTGTTTAGAGCCTAA
TTTGCAGAATTTAGAATTTTTGCAATCCTTTTTTTTGAGCATGTTGGATCTTGCCCCTTCAAGGGATAAAGAAGCCTTAG
AAGACATGAATGCGATTTCTGGCGCGATTAAGAGCCTTTATGAGACCTTATACCCCAAAGATTTTAGTTTGCTGGATTTT
AAAGAAACGCTTAAAAGAACCTCATCTAACCAATTGGGCTTGAGTTTAGAGCCGTATTTGAATAACCCCCTTTTTAACGC
TTTGAATGACGCGTTCAACTCCAACGCTTTTTTAAATGTGATAAACCTAGATGCGATCACCCAAAACCCTAAAGACTTAG
GGCTTTTAGCCTATTACTTGTTTTATAAGATCTTAGAAGAGTCTAGGAAAAACGACAGCGGCTTTTTGGTTTTTTTAGAC
GAATTTAAATCCTATGTGGAAAACGATTTGTTAAACACTAAAATCAACGCTTTAATCACGCAAGCCAGGAAAGCTAATGG
CGTGGTGGTGTTGGCCTTGCAAGACATTTACCAACTTAGCGGGGTTAAAAACGCCCATAGTTTTTTAAGCAACATGGGGA
CTCTCATTTTGTATCCGCAAAAAAACGCTAGGGAATTGAAACACAATTTCAATGTGCCTTTGAGCGAAACTGAAATTTCT
TTTTTAGAAAACACCCCTCTGTATGCCAGGCAGGTTTTAGTCAAAAATCTGGGTAACGGGAGTTCCAACATGATTGATGT
GAGTTTGGAGGGCTTGGGGTGTTATTTGAAAATCTTTAATTCAGATTCCAGTCATGTCAATAAAGTGAAAGCGTTACAAA
AAGACTACCCTACAGAGTGGCGTGAGAAACTTTTGAAGAGTTAG

Domains

Predicted by InterproScan.

CagE, TrbE, VirB family, component of type IV transporter system (CagE_TrbE_VirB)

(176-375)

FtsK/SpoIIIE family (FtsK_SpoIIIE)

(426-466)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9ZN44

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB4 Helicobacter pylori 26695

97.078

100

0.971