Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   LUA78_RS00860 Genome accession   NZ_CP089283
Coordinates   184944..186728 (+) Length   594 a.a.
NCBI ID   WP_000774433.1    Uniprot ID   -
Organism   Helicobacter pylori strain J99 derivative isolate D1     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 179944..191728
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LUA78_RS00825 (LUA78_00825) - 179951..180301 (+) 351 Protein_164 osmoprotection protein -
  LUA78_RS00830 (LUA78_00830) - 180313..180885 (-) 573 WP_000916528.1 Hpy99I family type II restriction endonuclease -
  LUA78_RS00835 (LUA78_00835) - 180879..181697 (-) 819 WP_000125523.1 DNA-methyltransferase -
  LUA78_RS00840 (LUA78_00840) - 181993..183654 (+) 1662 WP_234618075.1 glycine betaine ABC transporter substrate-binding protein -
  LUA78_RS00845 (LUA78_00845) - 183657..184307 (+) 651 WP_000659408.1 ATP-binding cassette domain-containing protein -
  LUA78_RS00850 (LUA78_00850) - 184311..184490 (-) 180 WP_001872805.1 hypothetical protein -
  LUA78_RS00855 (LUA78_00855) - 184482..184943 (+) 462 WP_000437154.1 hypothetical protein -
  LUA78_RS00860 (LUA78_00860) uvrC 184944..186728 (+) 1785 WP_000774433.1 excinuclease ABC subunit UvrC Machinery gene
  LUA78_RS00865 (LUA78_00865) - 186738..188003 (+) 1266 WP_046655446.1 homoserine dehydrogenase -
  LUA78_RS00870 (LUA78_00870) - 188004..188348 (+) 345 WP_001211704.1 YraN family protein -
  LUA78_RS00875 (LUA78_00875) trxA 188440..188760 (+) 321 WP_000020199.1 thioredoxin -
  LUA78_RS00880 (LUA78_00880) trxB 188766..189701 (+) 936 WP_000564402.1 thioredoxin-disulfide reductase -
  LUA78_RS00885 (LUA78_00885) - 190068..190889 (+) 822 WP_001263351.1 glycosyltransferase family 25 protein -
  LUA78_RS00890 (LUA78_00890) - 191099..191347 (-) 249 WP_000790555.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68671.84 Da        Isoelectric Point: 9.7127

>NTDB_id=636090 LUA78_RS00860 WP_000774433.1 184944..186728(+) (uvrC) [Helicobacter pylori strain J99 derivative isolate D1]
MADLLSSLKNLSSSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNPRTSLRVQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSIDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDRILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKDSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTISHTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASDQEKNAVLKKRK

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=636090 LUA78_RS00860 WP_000774433.1 184944..186728(+) (uvrC) [Helicobacter pylori strain J99 derivative isolate D1]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAGTAGTAGTGGGGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTACATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTGTCCGTAATAATGAAATCACGCCCA
ATCCTCGCACAAGCTTACGCGTCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTGATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCTATTGATTTCCCTATCCCTTTAATCACACGAAAAATCTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAATTGCTCCCTTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACTAA
AGAAGAATATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCTTAATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGTGGGAACAACAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTCAACGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATCTTATTGAGC
GCTTGTTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATCTCTCACCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAGGGTGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCGGATCTTAGAAGAAGCGCGATCGCTCTTCAATTTAGAGTGCGTGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTTCAAAAAGACTCTTATCGGCG
CTACCATCTAAAAGGCTCTAACGAATATGATCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATAGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGTTCTAAAGGGGGTGCTAAAGACATTAT
CCATACGATTAGTCATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGATCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAAAATAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.121

99.832

0.96