Detailed information NTG0635604

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LTK18_RS06465
• Genome accession: NZ_CP089165
• Coordinates: 1310780..1311823 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UNC_SaCF07
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1305780..1316823

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LTK18_RS06435 (LTK18_06435)	-	1306206..1306316 (+)	111	WP_001790257.1	hypothetical protein	-
LTK18_RS06440 (LTK18_06440)	-	1306345..1306758 (+)	414	WP_001557448.1	hypothetical protein	-
LTK18_RS06445 (LTK18_06445)	-	1307189..1308175 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
LTK18_RS06450 (LTK18_06450)	map	1308706..1309464 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LTK18_RS06455 (LTK18_06455)	-	1309681..1310067 (+)	387	WP_001110179.1	hypothetical protein	-
LTK18_RS06460 (LTK18_06460)	liaF	1310082..1310783 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LTK18_RS06465 (LTK18_06465)	vraS	1310780..1311823 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LTK18_RS06470 (LTK18_06470)	vraR	1311813..1312442 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LTK18_RS06475 (LTK18_06475)	-	1312555..1313772 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LTK18_RS06480 (LTK18_06480)	-	1314050..1314325 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LTK18_RS06485 (LTK18_06485)	-	1314332..1314796 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LTK18_RS06490 (LTK18_06490)	-	1314943..1315143 (+)	201	WP_000180460.1	DUF1128 family protein	-
LTK18_RS06495 (LTK18_06495)	-	1315146..1316402 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=635604 LTK18_RS06465 WP_001017131.1 1310780..1311823(+) (vraS) [Staphylococcus aureus strain UNC_SaCF07]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=635604 LTK18_RS06465 WP_001017131.1 1310780..1311823(+) (vraS) [Staphylococcus aureus strain UNC_SaCF07]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1