Detailed information NTG0635549

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LTK21_RS13155
• Genome accession: NZ_CP089161
• Coordinates: 2678312..2679355 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UNC_SaCF13
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2673312..2684355

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LTK21_RS13125 (LTK21_13125)	-	2673733..2674989 (-)	1257	WP_001795108.1	aminopeptidase	-
LTK21_RS13130 (LTK21_13130)	-	2674992..2675192 (-)	201	WP_000180460.1	DUF1128 family protein	-
LTK21_RS13135 (LTK21_13135)	-	2675339..2675803 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LTK21_RS13140 (LTK21_13140)	-	2675810..2676085 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LTK21_RS13145 (LTK21_13145)	-	2676363..2677580 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LTK21_RS13150 (LTK21_13150)	vraR	2677693..2678322 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LTK21_RS13155 (LTK21_13155)	vraS	2678312..2679355 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LTK21_RS13160 (LTK21_13160)	liaF	2679352..2680053 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LTK21_RS13165 (LTK21_13165)	-	2680068..2680454 (-)	387	WP_001110179.1	hypothetical protein	-
LTK21_RS13170 (LTK21_13170)	map	2680671..2681429 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LTK21_RS13175 (LTK21_13175)	-	2681960..2682946 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
LTK21_RS13180 (LTK21_13180)	-	2683377..2683790 (-)	414	WP_001557448.1	hypothetical protein	-
LTK21_RS13185 (LTK21_13185)	-	2683819..2683929 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=635549 LTK21_RS13155 WP_001017131.1 2678312..2679355(-) (vraS) [Staphylococcus aureus strain UNC_SaCF13]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=635549 LTK21_RS13155 WP_001017131.1 2678312..2679355(-) (vraS) [Staphylococcus aureus strain UNC_SaCF13]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1