Detailed information NTG0631074

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LP473_RS11235
• Genome accession: NZ_CP087699
• Coordinates: 2238927..2239955 (-)
• Length: 342 a.a.
• NCBI ID: WP_003132657.1
• Uniprot ID: S6FVM6
• Organism: Lactococcus lactis subsp. lactis strain IBB417
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2233927..2244955

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LP473_RS11205 (LP473_11210)	-	2234208..2234705 (-)	498	WP_003132662.1	nitroreductase family protein	-
LP473_RS11210 (LP473_11215)	-	2234692..2234901 (-)	210	WP_003132661.1	hypothetical protein	-
LP473_RS11215 (LP473_11220)	-	2234898..2235725 (-)	828	WP_252174776.1	radical SAM protein	-
LP473_RS11220 (LP473_11225)	-	2235718..2236923 (-)	1206	WP_252174777.1	hypothetical protein	-
LP473_RS11225 (LP473_11230)	-	2236920..2237846 (-)	927	WP_228763250.1	radical SAM protein	-
LP473_RS11230 (LP473_11235)	-	2237949..2238806 (-)	858	WP_003132658.1	Rgg/GadR/MutR family transcriptional regulator	-
LP473_RS11235 (LP473_11240)	sepM	2238927..2239955 (-)	1029	WP_003132657.1	SepM family pheromone-processing serine protease	Regulator
LP473_RS11240 (LP473_11245)	coaD	2239942..2240439 (-)	498	WP_010906348.1	pantetheine-phosphate adenylyltransferase	-
LP473_RS11245 (LP473_11250)	rsmD	2240487..2241026 (-)	540	WP_003132655.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LP473_RS11250 (LP473_11255)	-	2241197..2242417 (-)	1221	WP_003132654.1	MFS transporter	-
LP473_RS11255 (LP473_11260)	lmrP	2242501..2243726 (-)	1226	Protein_2193	multidrug efflux MFS transporter LmrP	-
LP473_RS11260 (LP473_11265)	-	2243914..2244408 (+)	495	WP_012898649.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 342 a.a.
• Molecular weight: 37349.96 Da
• Isoelectric Point: 9.9183

>NTDB_id=631074 LP473_RS11235 WP_003132657.1 2238927..2239955(-) (sepM) [Lactococcus lactis subsp. lactis strain IBB417]
MKKNKKINPKLKWGISIGLIVVALLALFYPTSYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYSH
FNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAIYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELADTITAV
NGQQFTSSADMIAYVSKQKVGDSVTIEYTRIDGTKHKSTGKYIKIANGKTGIGISLVDHTEVVTTPKVTVNAGSIGGPSA
GMMFTLEIYSQLTGKDLRNGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAKK
LKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1029 bp

>NTDB_id=631074 LP473_RS11235 WP_003132657.1 2238927..2239955(-) (sepM) [Lactococcus lactis subsp. lactis strain IBB417]
ATGAAAAAAAATAAAAAAATTAATCCCAAATTAAAATGGGGAATCTCGATTGGTCTAATTGTTGTTGCCCTTTTAGCTTT
ATTTTATCCAACAAGTTACTATGTGGAAATGCCCGGAACAACCGAGCCTTTAGGAAAAATGGTCAAAGTTGAAGGCAAAA
AAGATGAACATAAAGGTGATTTTTTCCTGACGACTGTCCAAATTGCACGAGCAAATCTTGCTACAATGATTTACAGCCAT
TTTAATAGTTTTACAAGCATTTACAGTGAGCAAGAAATGACTGGTGGACTTAACGACGCACAGTTCAACCGTGTCAACCA
GTTTTACATGGAAACGGCACAGAATACAGCGATTTATCAAGCTTTTAAATTAGCTAATAAACCTTATGAACTTAAATATG
AAGGCGTTTATGTCCTTGATATTGCCAAAAATTCGACCTTTAAAAATAAGCTAGAACTTGCAGATACGATTACAGCAGTC
AATGGTCAACAGTTTACATCAAGTGCCGACATGATTGCTTATGTTTCCAAACAAAAAGTCGGTGATTCAGTAACGATTGA
ATACACGAGAATTGACGGCACAAAGCACAAGTCAACTGGCAAATACATCAAAATTGCTAATGGAAAAACAGGAATTGGGA
TCAGCCTAGTTGACCATACTGAAGTCGTGACGACTCCAAAAGTTACTGTCAACGCGGGTTCAATCGGTGGTCCCTCTGCG
GGGATGATGTTTACACTAGAAATTTACAGTCAGTTGACAGGAAAAGATTTGCGAAACGGTCGCGAAATTGCTGGAACTGG
GACGATTGAACATGACGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCCACAGCGAGCAAAGAAGGGGCAA
AGGTCTTCTTGGTGCCTGACTCAGGCACCAAAAAAGAAAGTAGCAACAATTACCTTGGAGCCAAAGCCGCCGCTAAAAAA
CTAAAAACGAAGATGAAAATCGTTCCCGTCAAAACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (134-194)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (227-338)

3D structure

• AlphaFold DB: S6FVM6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.491