Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   SAZ172_RS00455 Genome accession   NC_022604
Coordinates   93390..95018 (-) Length   542 a.a.
NCBI ID   WP_001186596.1    Uniprot ID   -
Organism   Staphylococcus aureus subsp. aureus Z172     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 40890..96385 93390..95018 within 0


Gene organization within MGE regions


Location: 40890..96385
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SAZ172_RS00165 (SAZ172_0033) ccrC 40890..42575 (+) 1686 WP_000676600.1 cassette chromosome recombinase CcrC -
  SAZ172_RS00170 (SAZ172_0034) tnpA 42623..43108 (+) 486 WP_000093392.1 IS200/IS605 family transposase -
  SAZ172_RS00175 (SAZ172_0035) - 43402..43740 (+) 339 WP_000175892.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SAZ172_RS00180 (SAZ172_0036) - 43834..44145 (+) 312 WP_001166716.1 DUF960 family protein -
  SAZ172_RS00185 (SAZ172_0037) - 44161..44667 (+) 507 WP_000848380.1 DUF1643 domain-containing protein -
  SAZ172_RS00190 (SAZ172_0038) - 44688..45005 (+) 318 WP_023180038.1 JAB domain-containing protein -
  SAZ172_RS00195 (SAZ172_0039) - 45124..46209 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  SAZ172_RS00200 (SAZ172_0040) - 46206..48098 (+) 1893 Protein_37 site-specific integrase -
  SAZ172_RS00210 (SAZ172_0042) - 48105..48482 (+) 378 WP_000361059.1 DUF6262 family protein -
  SAZ172_RS00215 (SAZ172_0043) - 48633..49415 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  SAZ172_RS00220 (SAZ172_0044) erm(A) 49541..50272 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  SAZ172_RS16985 - 50330..50389 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  SAZ172_RS00225 (SAZ172_0045) - 50781..51443 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  SAZ172_RS16805 - 51675..51821 (+) 147 Protein_43 JAB domain-containing protein -
  SAZ172_RS00230 (SAZ172_0046) - 51991..52863 (+) 873 WP_000373151.1 HTH domain-containing protein -
  SAZ172_RS00235 (SAZ172_0047) - 52920..53210 (+) 291 WP_000065262.1 hypothetical protein -
  SAZ172_RS00240 (SAZ172_0048) - 53226..53714 (+) 489 WP_000397419.1 hypothetical protein -
  SAZ172_RS00245 (SAZ172_0049) - 53849..54376 (+) 528 WP_000717928.1 hypothetical protein -
  SAZ172_RS00250 (SAZ172_0050) - 54439..54855 (+) 417 WP_000941331.1 hypothetical protein -
  SAZ172_RS16710 (SAZ172_0051) - 55144..55308 (+) 165 WP_001803222.1 hypothetical protein -
  SAZ172_RS00255 (SAZ172_0052) - 55322..55543 (+) 222 WP_001070883.1 hypothetical protein -
  SAZ172_RS00260 (SAZ172_0053) - 55695..56261 (+) 567 WP_000759939.1 PepSY domain-containing protein -
  SAZ172_RS00265 (SAZ172_0054) - 56341..58554 (-) 2214 Protein_52 type I restriction endonuclease subunit R -
  SAZ172_RS00270 (SAZ172_0055) - 58616..59290 (-) 675 WP_023180042.1 IS6 family transposase -
  SAZ172_RS00275 (SAZ172_0056) - 59573..60919 (+) 1347 WP_023180046.1 dihydrolipoyl dehydrogenase family protein -
  SAZ172_RS00280 (SAZ172_0057) merR 61219..61626 (+) 408 WP_000525462.1 Hg(II)-responsive transcriptional regulator MerR -
  SAZ172_RS00285 (SAZ172_0058) - 61643..62128 (+) 486 WP_000746202.1 TlpA family protein disulfide reductase -
  SAZ172_RS00290 (SAZ172_0059) - 62125..62805 (+) 681 WP_000010352.1 cytochrome c biogenesis CcdA family protein -
  SAZ172_RS00295 merT 62893..63279 (+) 387 WP_001794630.1 mercuric transport protein MerT -
  SAZ172_RS00300 (SAZ172_0060) merA 63337..64980 (+) 1644 WP_000193219.1 mercury(II) reductase -
  SAZ172_RS00305 (SAZ172_0061) merB 65062..65712 (+) 651 WP_000790333.1 organomercurial lyase MerB -
  SAZ172_RS00310 (SAZ172_0062) - 65907..66422 (-) 516 WP_000377078.1 hypothetical protein -
  SAZ172_RS00315 (SAZ172_0063) - 66541..67215 (-) 675 WP_001105968.1 IS6-like element IS257 family transposase -
  SAZ172_RS16810 (SAZ172_0064) - 67412..68299 (+) 888 WP_023180047.1 MFS transporter -
  SAZ172_RS16815 - 68256..68792 (+) 537 WP_235056558.1 MFS transporter -
  SAZ172_RS00325 (SAZ172_0065) mobV 68981..70222 (+) 1242 WP_000122374.1 MobV family relaxase -
  SAZ172_RS15665 (SAZ172_0066) - 70749..71703 (+) 955 Protein_66 replication initiation factor domain-containing protein -
  SAZ172_RS00340 - 71790..72458 (-) 669 Protein_67 IS6 family transposase -
  SAZ172_RS15670 - 72494..72883 (+) 390 WP_020444595.1 hydroxymethylglutaryl-CoA synthase -
  SAZ172_RS00350 (SAZ172_0070) - 73960..74703 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  SAZ172_RS00355 (SAZ172_0071) - 74800..75228 (+) 429 WP_000872606.1 MaoC family dehydratase -
  SAZ172_RS00360 (SAZ172_0072) mecA 75274..77283 (-) 2010 WP_078056052.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  SAZ172_RS00365 (SAZ172_0073) mecR1 77380..79137 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  SAZ172_RS00370 mecI 79137..79508 (+) 372 Protein_73 mecA-type methicillin resistance repressor MecI -
  SAZ172_RS16450 psm-mec 79593..79661 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  SAZ172_RS00375 (SAZ172_0075) - 79981..81129 (+) 1149 WP_000427807.1 ROK family transcriptional regulator -
  SAZ172_RS00385 (SAZ172_0077) cstB 81243..82577 (-) 1335 Protein_76 persulfide dioxygenase-sulfurtransferase CstB -
  SAZ172_RS00390 (SAZ172_0078) - 82609..83673 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  SAZ172_RS00395 (SAZ172_0079) cstR 83809..84069 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  SAZ172_RS00400 - 84069..84707 (+) 639 Protein_79 sulfite exporter TauE/SafE family protein -
  SAZ172_RS00405 (SAZ172_0081) - 84981..85597 (-) 617 Protein_80 CadD family cadmium resistance transporter -
  SAZ172_RS00410 (SAZ172_0082) - 85680..88094 (-) 2415 WP_023180052.1 heavy metal translocating P-type ATPase -
  SAZ172_RS00415 (SAZ172_0083) - 88087..88452 (-) 366 WP_000159127.1 ArsR/SmtB family transcription factor -
  SAZ172_RS00420 (SAZ172_0084) - 88638..89015 (-) 378 WP_001041908.1 DUF6262 family protein -
  SAZ172_RS00425 (SAZ172_0085) - 89022..90914 (-) 1893 WP_014532403.1 site-specific integrase -
  SAZ172_RS00430 (SAZ172_0086) - 91109..91432 (-) 324 WP_000088091.1 JAB domain-containing protein -
  SAZ172_RS00435 (SAZ172_0087) - 91425..91631 (-) 207 WP_001077283.1 hypothetical protein -
  SAZ172_RS00440 (SAZ172_0088) - 91633..92154 (-) 522 WP_000836008.1 DUF1643 domain-containing protein -
  SAZ172_RS00445 (SAZ172_0089) - 92173..92484 (-) 312 WP_000833212.1 DUF960 family protein -
  SAZ172_RS00450 - 92569..92919 (-) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SAZ172_RS00455 (SAZ172_0090) ccrB 93390..95018 (-) 1629 WP_001186596.1 cassette chromosome recombinase CcrB Machinery gene
  SAZ172_RS00460 (SAZ172_0091) ccrA 95039..96385 (-) 1347 WP_000816499.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62274.15 Da        Isoelectric Point: 9.7334

>NTDB_id=63031 SAZ172_RS00455 WP_001186596.1 93390..95018(-) (ccrB) [Staphylococcus aureus subsp. aureus Z172]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=63031 SAZ172_RS00455 WP_001186596.1 93390..95018(-) (ccrB) [Staphylococcus aureus subsp. aureus Z172]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAAAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(11-156)

Recombinase (Recombinase)

(180-280)

Ogr/Delta-like zinc finger (Ogr_Delta)

(301-356)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

86.531

100

0.865

Multiple sequence alignment