Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LN243_RS00430 Genome accession   NZ_CP086659
Coordinates   99432..100778 (+) Length   448 a.a.
NCBI ID   WP_000816499.1    Uniprot ID   Q9R3W9
Organism   Staphylococcus capitis strain XZ03     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 99432..120920 99432..100778 within 0


Gene organization within MGE regions


Location: 99432..120920
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LN243_RS00430 ccrA 99432..100778 (+) 1347 WP_000816499.1 cassette chromosome recombinase CcrA Machinery gene
  LN243_RS00435 ccrB 100799..102427 (+) 1629 WP_001186596.1 cassette chromosome recombinase CcrB Machinery gene
  LN243_RS00440 - 102898..103248 (+) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LN243_RS00445 - 103333..103644 (+) 312 WP_000833212.1 DUF960 family protein -
  LN243_RS00450 - 103663..104184 (+) 522 WP_000836008.1 DUF1643 domain-containing protein -
  LN243_RS00455 - 104186..104392 (+) 207 WP_001077283.1 hypothetical protein -
  LN243_RS00460 - 104385..104708 (+) 324 WP_030063452.1 JAB domain-containing protein -
  LN243_RS00465 - 104827..105912 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  LN243_RS00470 - 105909..107801 (+) 1893 WP_001557544.1 site-specific integrase -
  LN243_RS00475 - 107808..108185 (+) 378 WP_000361059.1 DUF6262 family protein -
  LN243_RS00480 - 108336..109118 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  LN243_RS00485 erm(A) 109244..109975 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  LN243_RS12640 - 110033..110092 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  LN243_RS00490 - 110484..111146 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  LN243_RS00500 - 111491..112129 (-) 639 Protein_97 sulfite exporter TauE/SafE family protein -
  LN243_RS00505 cstR 112129..112389 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  LN243_RS00510 - 112525..113589 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  LN243_RS00515 cstB 113622..114956 (+) 1335 Protein_100 persulfide dioxygenase-sulfurtransferase CstB -
  LN243_RS00520 - 115070..116200 (-) 1131 WP_010922808.1 ROK family transcriptional regulator -
  LN243_RS00525 psm-mec 116533..116601 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  LN243_RS00530 mecI 116686..117057 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  LN243_RS00535 mecR1 117057..118814 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  LN243_RS00540 mecA 118911..120920 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 52138.19 Da        Isoelectric Point: 10.1760

>NTDB_id=626005 LN243_RS00430 WP_000816499.1 99432..100778(+) (ccrA) [Staphylococcus capitis strain XZ03]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=626005 LN243_RS00430 WP_000816499.1 99432..100778(+) (ccrA) [Staphylococcus capitis strain XZ03]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(168-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9R3W9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

78.174

100

0.783
  ccrA Staphylococcus aureus N315

72.383

100

0.725