Detailed information NTG0062413

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SA40_RS09435
• Genome accession: NC_022443
• Coordinates: 1914256..1915299 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus SA40
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1909256..1920299

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SA40_RS09405 (SA40_1719)	-	1909677..1910933 (-)	1257	WP_078065149.1	aminopeptidase	-
SA40_RS09410 (SA40_1720)	-	1910936..1911136 (-)	201	WP_000180460.1	DUF1128 family protein	-
SA40_RS09415 (SA40_1721)	-	1911283..1911747 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SA40_RS09420 (SA40_1722)	-	1911754..1912029 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SA40_RS09425 (SA40_1723)	-	1912307..1913524 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
SA40_RS09430 (SA40_1724)	vraR	1913637..1914266 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
SA40_RS09435 (SA40_1725)	vraS	1914256..1915299 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SA40_RS09440 (SA40_1726)	liaF	1915296..1915997 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SA40_RS09445 (SA40_1727)	-	1916012..1916398 (-)	387	WP_001110179.1	hypothetical protein	-
SA40_RS09450 (SA40_1728)	map	1916615..1917373 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SA40_RS09455 (SA40_1729)	-	1917902..1918888 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
SA40_RS09460 (SA40_1730)	-	1919321..1919734 (-)	414	WP_025174552.1	hypothetical protein	-
SA40_RS09465	-	1919763..1919873 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=62413 SA40_RS09435 WP_001017131.1 1914256..1915299(-) (vraS) [Staphylococcus aureus subsp. aureus SA40]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=62413 SA40_RS09435 WP_001017131.1 1914256..1915299(-) (vraS) [Staphylococcus aureus subsp. aureus SA40]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1