Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   SA40_RS00210 Genome accession   NC_022443
Coordinates   48812..50161 (-) Length   449 a.a.
NCBI ID   WP_021758189.1    Uniprot ID   Q3YK46
Organism   Staphylococcus aureus subsp. aureus SA40     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 40397..55442 48812..50161 within 0


Gene organization within MGE regions


Location: 40397..55442
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SA40_RS00170 (SA40_0033) mecA 40397..42406 (-) 2010 WP_063852655.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  SA40_RS00175 (SA40_0034) - 42503..43489 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  SA40_RS00180 (SA40_0035) - 43461..43721 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  SA40_RS00185 (SA40_0036) - 43712..45319 (-) 1608 Protein_34 IS1182 family transposase -
  SA40_RS00190 (SA40_0037) - 45371..45877 (-) 507 WP_001092195.1 DUF1643 domain-containing protein -
  SA40_RS00195 (SA40_0038) - 45892..46203 (-) 312 WP_021758187.1 DUF960 domain-containing protein -
  SA40_RS00200 - 46290..46640 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SA40_RS00205 (SA40_0040) ccrB 47162..48790 (-) 1629 WP_021758188.1 recombinase family protein Machinery gene
  SA40_RS00210 (SA40_0041) ccrA 48812..50161 (-) 1350 WP_021758189.1 recombinase family protein Machinery gene
  SA40_RS00215 (SA40_0042) - 50395..52188 (-) 1794 WP_021758190.1 DUF927 domain-containing protein -
  SA40_RS00220 (SA40_0043) - 52188..52481 (-) 294 WP_021758191.1 single-stranded DNA-binding protein -
  SA40_RS00230 (SA40_0045) - 52716..53857 (+) 1142 WP_089535815.1 IS3 family transposase -
  SA40_RS00235 (SA40_0046) - 53928..55442 (-) 1515 WP_021758193.1 hypothetical protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52568.15 Da        Isoelectric Point: 9.9150

>NTDB_id=62380 SA40_RS00210 WP_021758189.1 48812..50161(-) (ccrA) [Staphylococcus aureus subsp. aureus SA40]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQVTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTSSDNQLKQKIKCPCCNATLTNMTVRKKNHILRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLHQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=62380 SA40_RS00210 WP_021758189.1 48812..50161(-) (ccrA) [Staphylococcus aureus subsp. aureus SA40]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAGTAACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATTAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCGTTAGAAAAAAGAATCATATATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTATGTGATTTCAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACATCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YK46

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

98.218

100

0.982
  ccrA Staphylococcus aureus COL

74.61

100

0.746

Multiple sequence alignment