Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   KW2_RS11035 Genome accession   NC_022369
Coordinates   2293412..2294443 (-) Length   343 a.a.
NCBI ID   WP_021037973.1    Uniprot ID   A0A166JD06
Organism   Lactococcus cremoris subsp. cremoris KW2     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 2288412..2299443
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KW2_RS12185 - 2289403..2289546 (-) 144 WP_155723358.1 hypothetical protein -
  KW2_RS11020 (kw2_2218) - 2289617..2290474 (-) 858 WP_021037970.1 Rgg/GadR/MutR family transcriptional regulator -
  KW2_RS11025 (kw2_2219) - 2290526..2291662 (-) 1137 WP_011836074.1 MFS transporter -
  KW2_RS11030 (kw2_2220) kwcM 2291659..2292783 (-) 1125 WP_021037971.1 KxxxW cyclic peptide radical SAM maturase -
  KW2_RS11990 (kw2_2222) - 2292979..2293092 (-) 114 WP_011836076.1 KxxxW-cyclized peptide pheromone -
  KW2_RS11035 (kw2_2223) sepM 2293412..2294443 (-) 1032 WP_021037973.1 SepM family pheromone-processing serine protease Regulator
  KW2_RS11040 (kw2_2224) coaD 2294427..2294927 (-) 501 WP_021037974.1 pantetheine-phosphate adenylyltransferase -
  KW2_RS11045 (kw2_2225) rsmD 2294975..2295514 (-) 540 WP_021037975.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  KW2_RS11050 (kw2_2226) - 2295687..2296904 (-) 1218 WP_021037976.1 MDR family MFS transporter -
  KW2_RS11055 (kw2_2227) lmrP 2296988..2298214 (-) 1227 WP_021037977.1 multidrug efflux MFS transporter LmrP -

Sequence

Protein


Download         Length: 343 a.a.        Molecular weight: 37402.08 Da        Isoelectric Point: 9.9058

>NTDB_id=62286 KW2_RS11035 WP_021037973.1 2293412..2294443(-) (sepM) [Lactococcus cremoris subsp. cremoris KW2]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGMMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALTYLEK

Nucleotide


Download         Length: 1032 bp        

>NTDB_id=62286 KW2_RS11035 WP_021037973.1 2293412..2294443(-) (sepM) [Lactococcus cremoris subsp. cremoris KW2]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGGAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTCTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCATTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATTGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGCAGTAAGCACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATGATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGACTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGCGGTGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACCATTCAAGACGCTTTAACTTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(229-339)

PDZ domain (PDZ_2)

(135-193)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A166JD06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

48.406

100

0.487

Multiple sequence alignment