Detailed information NTG0062272

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: KW2_RS07715
• Genome accession: NC_022369
• Coordinates: 1637234..1637926 (-)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris subsp. cremoris KW2
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1632234..1642926

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KW2_RS07695 (kw2_1545)	murD	1632380..1633729 (-)	1350	WP_021037556.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
KW2_RS07700 (kw2_1546)	-	1633898..1634239 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
KW2_RS07705 (kw2_1547)	-	1634322..1635563 (-)	1242	WP_021037557.1	ammonium transporter	-
KW2_RS07710 (kw2_1548)	covS	1635749..1637221 (-)	1473	WP_021037558.1	HAMP domain-containing sensor histidine kinase	Regulator
KW2_RS07715 (kw2_1549)	covR	1637234..1637926 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
KW2_RS07720 (kw2_1550)	-	1638083..1638613 (-)	531	WP_021037559.1	YceD family protein	-
KW2_RS07725 (kw2_1551)	-	1638746..1638991 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
KW2_RS07730 (kw2_1552)	-	1639315..1639677 (-)	363	WP_021037560.1	TIGR02328 family protein	-
KW2_RS07735 (kw2_1553)	-	1639914..1640825 (-)	912	WP_021037561.1	CHAP domain-containing protein	-
KW2_RS07740 (kw2_1554)	-	1640918..1641754 (-)	837	WP_021037562.1	metallophosphoesterase	-
KW2_RS07745 (kw2_1555)	arsC	1641866..1642270 (-)	405	WP_021037563.1	arsenate reductase (thioredoxin)	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=62272 KW2_RS07715 WP_011676631.1 1637234..1637926(-) (covR) [Lactococcus cremoris subsp. cremoris KW2]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=62272 KW2_RS07715 WP_011676631.1 1637234..1637926(-) (covR) [Lactococcus cremoris subsp. cremoris KW2]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCACGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGTGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACATTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361