Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   LK447_RS06920 Genome accession   NZ_CP085947
Coordinates   1446041..1447825 (+) Length   594 a.a.
NCBI ID   WP_000774307.1    Uniprot ID   B5Z7I6
Organism   Helicobacter pylori strain FDAARGOS_1563     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1441041..1452825
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LK447_RS06885 (LK447_06885) - 1441094..1441441 (+) 348 Protein_1349 osmoprotection protein -
  LK447_RS06890 (LK447_06890) - 1441455..1442027 (-) 573 WP_000916527.1 Hpy99I family type II restriction endonuclease -
  LK447_RS06895 (LK447_06895) - 1442021..1442839 (-) 819 WP_000125522.1 site-specific DNA-methyltransferase -
  LK447_RS06900 (LK447_06900) - 1443090..1444751 (+) 1662 WP_000901309.1 ABC transporter permease/substrate-binding protein -
  LK447_RS06905 (LK447_06905) - 1444755..1445396 (+) 642 WP_000659460.1 ATP-binding cassette domain-containing protein -
  LK447_RS06910 (LK447_06910) - 1445408..1445587 (-) 180 WP_000468793.1 hypothetical protein -
  LK447_RS06915 (LK447_06915) - 1445579..1446040 (+) 462 WP_000437179.1 hypothetical protein -
  LK447_RS06920 (LK447_06920) uvrC 1446041..1447825 (+) 1785 WP_000774307.1 excinuclease ABC subunit UvrC Machinery gene
  LK447_RS06925 (LK447_06925) - 1447836..1449101 (+) 1266 WP_000746771.1 homoserine dehydrogenase -
  LK447_RS06930 (LK447_06930) - 1449102..1449446 (+) 345 WP_001210426.1 YraN family protein -
  LK447_RS06935 (LK447_06935) trxA 1449535..1449855 (+) 321 WP_000020206.1 thioredoxin -
  LK447_RS06940 (LK447_06940) trxB 1449861..1450796 (+) 936 WP_000564376.1 thioredoxin-disulfide reductase -
  LK447_RS06945 (LK447_06945) - 1451005..1451826 (+) 822 WP_001263398.1 glycosyltransferase family 25 protein -
  LK447_RS06950 (LK447_06950) - 1452049..1452297 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68591.79 Da        Isoelectric Point: 9.4801

>NTDB_id=621496 LK447_RS06920 WP_000774307.1 1446041..1447825(+) (uvrC) [Helicobacter pylori strain FDAARGOS_1563]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSICNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
ACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEVRSLFNLECVPYRVEIFDT
SHHANSQCVGGMVVYENNEFQKDSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=621496 LK447_RS06920 WP_000774307.1 1446041..1447825(+) (uvrC) [Helicobacter pylori strain FDAARGOS_1563]
ATGGCTGATTTATTGTCCAGTTTAAAAAACCTTCCTAACAGCAGTGGCGTGTATCAATACTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCTGTAATAATGAAATCACGCCCA
ACCATCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCCTATATTTATATGGATTTTTCCACCGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAAGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGCAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCTCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAGGCGATGAAACAAGCCATTATCAATCATTACCAATCTCATTTGCCTTTGATACCAGAACAGATTTTATTGAAC
GCTTGTTCTAATGAAGCGCTTAAAGAATTGCAAGAGTTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAGGGCGACAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGTGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAATGAATTTCAAAAAGATTCTTATCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAGTTGCTCACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B5Z7I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.475

100

0.975