Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   LK454_RS02335 Genome accession   NZ_CP085923
Coordinates   478455..480239 (+) Length   594 a.a.
NCBI ID   WP_000774325.1    Uniprot ID   -
Organism   Helicobacter pylori strain FDAARGOS_1601     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 473455..485239
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LK454_RS02305 (LK454_02305) motB 474219..474992 (+) 774 WP_001085348.1 flagellar motor protein MotB -
  LK454_RS02310 (LK454_02310) - 474998..475435 (+) 438 WP_001885597.1 hypothetical protein -
  LK454_RS02315 (LK454_02315) - 475515..477167 (+) 1653 WP_000537977.1 ABC transporter permease/substrate-binding protein -
  LK454_RS02320 (LK454_02320) - 477169..477810 (+) 642 WP_000659455.1 ATP-binding cassette domain-containing protein -
  LK454_RS02325 (LK454_02325) - 477822..478001 (-) 180 WP_000468793.1 hypothetical protein -
  LK454_RS02330 (LK454_02330) - 477993..478454 (+) 462 WP_000437210.1 hypothetical protein -
  LK454_RS02335 (LK454_02335) uvrC 478455..480239 (+) 1785 WP_000774325.1 excinuclease ABC subunit UvrC Machinery gene
  LK454_RS02340 (LK454_02340) - 480250..481515 (+) 1266 WP_000746778.1 homoserine dehydrogenase -
  LK454_RS02345 (LK454_02345) - 481516..481860 (+) 345 WP_001211718.1 YraN family protein -
  LK454_RS02350 (LK454_02350) trxA 481949..482269 (+) 321 WP_000020210.1 thioredoxin -
  LK454_RS02355 (LK454_02355) trxB 482274..483209 (+) 936 WP_054833688.1 thioredoxin-disulfide reductase -
  LK454_RS02360 (LK454_02360) - 483567..484388 (+) 822 WP_054833689.1 glycosyltransferase family 25 protein -
  LK454_RS02365 (LK454_02365) - 484610..484858 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68630.84 Da        Isoelectric Point: 9.7129

>NTDB_id=621285 LK454_RS02335 WP_000774325.1 478455..480239(+) (uvrC) [Helicobacter pylori strain FDAARGOS_1601]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRVQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSTFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNEVLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENHAFQKDSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=621285 LK454_RS02335 WP_000774325.1 478455..480239(+) (uvrC) [Helicobacter pylori strain FDAARGOS_1601]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAACAGCAGTGGCGTGTATCAATACTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAAGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCTATCCGTAATAATGAAATCACGCCCA
ACCATCGCGCAAGCTTACGCGTCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTGATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAATTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACTAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTAATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTATGATTTGGACATTTTTGCTTTTTATGGCGCAAGCAATAAAGCGGT
GTTGGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAACATTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATTCTATTAAAC
GCTTGTTCTAATGAAGTGCTTAAAGAATTGCAAGAGTTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAGGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGCATTTCAAAAAGACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CACCGCCTAATTTGTGGGTAATAGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCCATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.639

99.832

0.975