Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   SIR_RS11755 Genome accession   NC_022246
Coordinates   375269..377536 (-) Length   755 a.a.
NCBI ID   WP_021002484.1    Uniprot ID   T1ZDH5
Organism   Streptococcus intermedius B196     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 370269..382536
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS11725 (SIR_0391) - 370300..370554 (+) 255 WP_021002481.1 hypothetical protein -
  SIR_RS11730 (SIR_0392) - 370566..372620 (+) 2055 WP_021002482.1 cation:proton antiporter -
  SIR_RS11735 (SIR_0393) - 372695..372994 (-) 300 WP_003071940.1 DUF1827 family protein -
  SIR_RS11740 (SIR_0394) - 373058..373507 (-) 450 WP_021002483.1 NUDIX hydrolase -
  SIR_RS11745 (SIR_0395) - 373664..374557 (+) 894 WP_003077000.1 helix-turn-helix transcriptional regulator -
  SIR_RS11750 (SIR_0396) - 374617..375222 (+) 606 WP_003071947.1 GyrI-like domain-containing protein -
  SIR_RS11755 (SIR_0397) clpE 375269..377536 (-) 2268 WP_021002484.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SIR_RS11760 (SIR_0398) - 377776..378006 (+) 231 WP_003023686.1 DUF1797 family protein -
  SIR_RS11765 (SIR_0399) - 378159..378701 (+) 543 WP_003077029.1 ClbS/DfsB family four-helix bundle protein -
  SIR_RS11775 (SIR_0400) - 379145..380533 (-) 1389 WP_003071961.1 ABC transporter permease -
  SIR_RS11780 (SIR_0401) - 380557..381204 (-) 648 WP_003071962.1 ABC transporter ATP-binding protein -
  SIR_RS11785 (SIR_0402) - 381216..382508 (-) 1293 WP_009569159.1 ABC transporter permease -

Sequence

Protein


Download         Length: 755 a.a.        Molecular weight: 84375.58 Da        Isoelectric Point: 5.1584

>NTDB_id=61869 SIR_RS11755 WP_021002484.1 375269..377536(-) (clpE) [Streptococcus intermedius B196]
MLCQNCKINESTIHLYTNVNGKQHQVDLCQNCYQIMKTDPNNALFRGMTNMNNQNNLDPFDDFFSNIGNFQNHQEPQTPP
TQSGGGYGNGGYGSNQGNSTRQQAPQQPKGLLEEFGINVTEFARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEPG
VGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMNEIRSRQDVILFIDEIHEIVGAGSAG
DGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDDAI
EAAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLVEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQ
QNKMADQDTPLISEKTIEHIIEQKTNIPVGDLKEKEQSQLISLADDLKTHVIGQDDAVDKIAKAIRRNRVGLGTPNRPIG
SFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILLDEI
EKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEANVGFGAAREGRTNSVIGELGNFFSPEFMNRFD
GIIEFKSLSKENLLQIVDLMLKDVNERLATNDIYLDVTDKVKEKLVNLGYDPKMGARPLRRTIQDHIEDAITDYYLEHPS
DKELKAIMTSNGKIVIKPAKKSENKSKTTIDNNAN

Nucleotide


Download         Length: 2268 bp        

>NTDB_id=61869 SIR_RS11755 WP_021002484.1 375269..377536(-) (clpE) [Streptococcus intermedius B196]
ATGCTTTGTCAAAACTGTAAAATAAATGAATCTACCATTCATCTTTACACAAATGTTAATGGGAAACAACATCAAGTTGA
CCTCTGTCAAAATTGTTATCAAATCATGAAAACGGATCCAAACAATGCCTTATTTCGTGGCATGACCAATATGAATAATC
AAAACAACCTAGACCCATTTGATGATTTCTTTAGCAATATAGGGAATTTTCAAAATCATCAAGAACCGCAGACTCCTCCT
ACTCAATCAGGTGGTGGATATGGCAATGGAGGCTATGGCTCCAATCAAGGCAATAGTACACGCCAACAAGCACCACAGCA
ACCTAAAGGTCTCCTAGAAGAATTCGGTATCAATGTGACTGAATTTGCTCGGCGTGGTGAAATTGACCCCGTGATTGGTC
GTGATGAGGAAATTGTTCGTGTTATTGAAATCCTCAATCGTAGAACGAAGAACAACCCTGTCCTCATCGGAGAGCCCGGT
GTCGGTAAAACAGCAGTTGTCGAAGGCTTGGCTCAGAAAATTGTAGACGGTGATGTGCCACATAAACTCCAAGGCAAAGA
AGTTATCCGCTTAGATGTCGTTAGCTTGGTTCAAGGAACTGGTATCCGTGGTCAATTTGAAGAACGAATGCAAAAACTTA
TGAACGAAATTCGCTCTCGTCAGGATGTGATATTATTCATTGATGAAATTCACGAAATTGTTGGAGCTGGTTCTGCCGGT
GATGGAAATATGGATGCTGGAAACATTCTAAAACCAGCACTTGCTCGCGGTGAACTCCAATTAGTTGGTGCCACAACTCT
CAATGAATACCGGATTATCGAAAAAGATGCTGCACTGGAACGCCGTATGCAGCCTGTAAAAGTTGATGAACCAACAGTTG
AAGAAACGATCACTATCCTCAAAGGTATTCAAAAGAAATACGAAGACTATCACCACGTCAAATACACCGACGATGCCATT
GAAGCAGCAGCTGTCTTGTCCAATCGGTATATCCAAGATCGCTTCTTGCCTGATAAGGCCATTGACTTGCTAGATGAAGC
AGGCTCTAAGATGAATCTGACACTTAACTTTGTCGATCCAAAAGTCATTGATCAACGATTGGTAGAAGCTGAAAATCTCA
AGGCACAAGCTACTCGTGATGAAGATTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCCAAATACAAAGAAATGCAG
CAAAATAAAATGGCTGATCAAGATACGCCTCTTATCAGTGAAAAAACCATTGAACATATCATTGAGCAAAAGACCAATAT
TCCAGTTGGCGACTTGAAAGAAAAGGAACAATCACAATTGATTAGTCTGGCTGATGATTTGAAAACTCATGTCATTGGTC
AAGATGATGCTGTTGATAAAATTGCCAAAGCTATTCGCCGTAATCGAGTTGGACTAGGTACACCAAACCGACCAATTGGT
TCTTTCCTTTTTGTTGGGCCAACCGGTGTCGGCAAAACAGAACTTTCTAAACAACTAGCGATTGAGCTCTTTGGTTCAGC
TGACAGCATGATTCGCTTTGATATGAGTGAGTATATGGAAAAACATAGCGTAGCAAAACTCGTCGGAGCGCCTCCAGGTT
ACGTTGGCTACGAAGAGGCTGGGCAATTAACAGAACGCGTACGTCGTAATCCTTATTCTCTCATTTTACTTGATGAAATA
GAAAAAGCTCACCCAGATGTCATGCATATGTTCTTGCAAGTACTGGATGACGGACGTCTGACAGATGGACAAGGTCGGAC
AGTCAGTTTCAAAGATACGATTATCATTATGACTTCCAACGCCGGTACTGGAAAAGTTGAAGCAAACGTCGGATTCGGTG
CAGCGCGTGAAGGACGAACCAATTCTGTTATCGGTGAATTAGGAAACTTCTTCAGTCCAGAATTTATGAACCGTTTTGAT
GGTATTATTGAGTTCAAATCTCTTAGCAAGGAAAATCTCCTACAAATCGTAGATTTGATGCTTAAAGATGTCAATGAACG
GCTTGCCACGAATGACATTTACCTAGATGTAACAGATAAAGTCAAGGAAAAATTAGTTAATCTTGGTTACGATCCGAAAA
TGGGAGCTCGTCCACTTCGTCGGACAATCCAAGATCACATTGAGGATGCTATCACTGACTACTATCTTGAACATCCAAGC
GACAAAGAGCTCAAAGCTATCATGACAAGTAATGGTAAGATTGTCATCAAACCAGCTAAAAAATCTGAGAATAAATCCAA
GACAACAATAGATAACAATGCTAATTAG

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(648-722)

ATPase family associated with various cellular activities (AAA) (AAA)

(154-273)

AAA domain (Cdc48 subfamily) (AAA_2)

(477-640)

AAA lid domain (AAA_lid_9)

(292-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZDH5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.898

99.073

0.861
  clpE Streptococcus pneumoniae D39

86.898

99.073

0.861
  clpE Streptococcus pneumoniae R6

86.898

99.073

0.861
  clpE Streptococcus pneumoniae TIGR4

86.898

99.073

0.861
  clpE Streptococcus mutans UA159

84.768

100

0.848
  clpC Lactococcus lactis subsp. cremoris KW2

76.923

99.868

0.768
  clpC Bacillus subtilis subsp. subtilis str. 168

49.857

92.45

0.461
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.546

86.358

0.411
  clpC Streptococcus pneumoniae Rx1

48.47

82.252

0.399
  clpC Streptococcus pneumoniae D39

48.47

82.252

0.399
  clpC Streptococcus pneumoniae TIGR4

48.309

82.252

0.397
  clpC Streptococcus thermophilus LMD-9

47.191

82.517

0.389
  clpC Streptococcus mutans UA159

46.372

83.974

0.389
  clpC Streptococcus thermophilus LMG 18311

47.115

82.649

0.389

Multiple sequence alignment