Detailed information NTG0617209

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LI754_RS10365
• Genome accession: NZ_CP085320
• Coordinates: 2085480..2086523 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CJFA-182
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2080480..2091523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LI754_RS10335	-	2080901..2082157 (-)	1257	WP_001789555.1	aminopeptidase	-
LI754_RS10340	-	2082160..2082360 (-)	201	WP_000180460.1	DUF1128 family protein	-
LI754_RS10345	-	2082507..2082971 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LI754_RS10350	-	2082978..2083253 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LI754_RS10355	-	2083531..2084748 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LI754_RS10360	vraR	2084861..2085490 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LI754_RS10365	vraS	2085480..2086523 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LI754_RS10370	liaF	2086520..2087221 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LI754_RS10375	-	2087236..2087622 (-)	387	WP_001110179.1	hypothetical protein	-
LI754_RS10380	map	2087839..2088597 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LI754_RS10385	-	2089128..2090114 (+)	987	WP_044290529.1	FUSC family protein	-
LI754_RS10390	-	2090545..2090958 (-)	414	WP_001566709.1	hypothetical protein	-
LI754_RS10395	-	2090987..2091097 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=617209 LI754_RS10365 WP_001017131.1 2085480..2086523(-) (vraS) [Staphylococcus aureus strain CJFA-182]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=617209 LI754_RS10365 WP_001017131.1 2085480..2086523(-) (vraS) [Staphylococcus aureus strain CJFA-182]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1