Detailed information NTG0617130

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LI911_RS00450
• Genome accession: NZ_CP085318
• Coordinates: 80408..81451 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CKFA-361
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 75408..86451

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LI911_RS00420	-	75715..75826 (+)	112	Protein_83	hypothetical protein	-
LI911_RS00425	-	75855..76268 (+)	414	WP_001566709.1	hypothetical protein	-
LI911_RS00430	-	76758..77744 (-)	987	WP_224851736.1	FUSC family protein	-
LI911_RS00435	map	78334..79092 (+)	759	WP_086353412.1	type I methionyl aminopeptidase	-
LI911_RS00440	-	79309..79695 (+)	387	WP_001110179.1	hypothetical protein	-
LI911_RS00445	liaF	79710..80411 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LI911_RS00450	vraS	80408..81451 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LI911_RS00455	vraR	81441..82070 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LI911_RS00460	-	82182..83399 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
LI911_RS00465	-	83677..83952 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LI911_RS00470	-	83959..84423 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LI911_RS00475	-	84570..84770 (+)	201	WP_000180460.1	DUF1128 family protein	-
LI911_RS00480	-	84773..86029 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=617130 LI911_RS00450 WP_001017131.1 80408..81451(+) (vraS) [Staphylococcus aureus strain CKFA-361]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=617130 LI911_RS00450 WP_001017131.1 80408..81451(+) (vraS) [Staphylococcus aureus strain CKFA-361]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1