Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   SCRE_RS07275 Genome accession   NC_022236
Coordinates   1465802..1468081 (+) Length   759 a.a.
NCBI ID   WP_006268257.1    Uniprot ID   F9P735
Organism   Streptococcus constellatus subsp. pharyngis C232     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1460802..1473081
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCRE_RS07255 (SCRE_1424) - 1461788..1462330 (-) 543 WP_020997988.1 ClbS/DfsB family four-helix bundle protein -
  SCRE_RS10090 (SCRE_1425) - 1462404..1462538 (-) 135 WP_003031275.1 FeoB-associated Cys-rich membrane protein -
  SCRE_RS07260 (SCRE_1426) feoB 1462547..1464692 (-) 2146 Protein_1443 ferrous iron transport protein B -
  SCRE_RS07265 (SCRE_1427) - 1464689..1465165 (-) 477 WP_003068195.1 FeoA family protein -
  SCRE_RS07270 (SCRE_1428) - 1465333..1465563 (-) 231 WP_006267994.1 DUF1797 family protein -
  SCRE_RS07275 (SCRE_1430) clpE 1465802..1468081 (+) 2280 WP_006268257.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SCRE_RS07280 (SCRE_1431) - 1468128..1468733 (-) 606 WP_006268194.1 GyrI-like domain-containing protein -
  SCRE_RS07285 (SCRE_1432) - 1468861..1469514 (-) 654 WP_006268402.1 helix-turn-helix transcriptional regulator -
  SCRE_RS10655 - 1469480..1469683 (-) 204 WP_003068185.1 helix-turn-helix transcriptional regulator -
  SCRE_RS07295 (SCRE_1433) - 1469840..1470289 (+) 450 Protein_1450 NUDIX hydrolase -
  SCRE_RS07300 (SCRE_1434) - 1470354..1470653 (+) 300 WP_006268083.1 DUF1827 family protein -
  SCRE_RS07305 (SCRE_1435) - 1471007..1471645 (-) 639 WP_321163008.1 IS982 family transposase -
  SCRE_RS07310 (SCRE_1436) - 1471875..1472420 (-) 546 WP_006268095.1 tRNA (mnm(5)s(2)U34)-methyltransferase -

Sequence

Protein


Download         Length: 759 a.a.        Molecular weight: 84780.97 Da        Isoelectric Point: 5.0266

>NTDB_id=61474 SCRE_RS07275 WP_006268257.1 1465802..1468081(+) (clpE) [Streptococcus constellatus subsp. pharyngis C232]
MLCQNCKINESTIHLYTNVNGKQHQVDLCQNCYQIMKTDPNNALFRGMTNMNNQNNLDPFDDFFSNLGNFQNHQEPQTPP
TQSGGGYGNGGYGSNQGGSTRQQVPQQPKGLLEEFGINVTEFARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEPG
VGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMNEIRSRQDVILFIDEIHEIVGAGSAG
DGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDDAI
EAAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKIIDQRLVEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQ
QNKMADQDTPLISEKTIEHIIEQKTNIPVGDLKEKEQSQLISLADDLKAHVIGQDDAVDKIAKAIRRNRVGLGTPDRPIG
SFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILLDEI
EKAHPDVMHMFLQVLDDGRLTDGQGRTVNFKDTIIIMTSNAGTGKVEANVGFGAAREGRTNSVLSELGNFFSPEFINRFD
GIIEFKSLSKENLLQIVDLMLEDVNKRLAVNGIHLDVTDKVKEKLVNLGYDPKMGARPLRRTIQDHIEDAITDYYLEHPS
EKELKAVMTSNSKIVIKSSKKSENETEKEIKTTADDTAN

Nucleotide


Download         Length: 2280 bp        

>NTDB_id=61474 SCRE_RS07275 WP_006268257.1 1465802..1468081(+) (clpE) [Streptococcus constellatus subsp. pharyngis C232]
ATGCTTTGTCAAAATTGTAAAATAAACGAATCAACTATTCACCTTTACACAAATGTGAATGGAAAACAACACCAAGTTGA
CCTCTGTCAAAATTGTTATCAAATCATGAAAACAGACCCAAATAATGCCTTATTTCGTGGCATGACCAATATGAACAATC
AAAATAATTTAGACCCTTTTGATGATTTCTTTAGCAATCTAGGGAATTTTCAAAATCATCAAGAACCGCAGACCCCTCCT
ACTCAATCAGGTGGCGGATACGGTAACGGAGGCTATGGTTCCAATCAAGGTGGCAGCACGCGCCAACAAGTACCACAACA
ACCCAAAGGCCTCCTAGAAGAATTTGGTATCAATGTAACTGAATTTGCTCGGCGGGGCGAGATTGACCCTGTAATTGGTC
GTGACGAAGAAATTGTGCGCGTCATTGAAATCCTCAATCGTAGAACGAAGAACAATCCTGTCCTCATCGGAGAGCCCGGT
GTCGGTAAAACAGCAGTTGTCGAAGGCTTGGCTCAGAAAATTGTAGACGGTGATGTGCCACATAAACTCCAAGGCAAAGA
AGTCATTCGTTTAGATGTCGTTAGTTTGGTTCAAGGAACTGGTATCCGTGGTCAATTTGAAGAACGAATGCAAAAACTCA
TGAACGAAATTCGCTCTCGACAAGATGTTATATTATTCATTGATGAAATTCACGAAATTGTTGGAGCTGGTTCTGCTGGC
GATGGAAATATGGATGCTGGAAACATCCTAAAACCAGCACTTGCTCGCGGTGAACTCCAATTAGTCGGTGCCACAACTCT
CAATGAATACCGGATTATCGAAAAAGATGCTGCACTGGAACGCCGTATGCAGCCTGTAAAAGTTGATGAACCAACAGTTG
AAGAAACGATCACTATCCTCAAAGGTATTCAAAAGAAATACGAAGACTATCACCACGTCAAATACACAGACGATGCCATT
GAAGCAGCAGCTGTCTTGTCCAATCGTTATATCCAAGATCGCTTCTTGCCTGATAAGGCCATTGACTTGCTAGACGAAGC
AGGCTCTAAGATGAATCTGACACTTAACTTTGTCGATCCAAAAATCATTGATCAACGATTGGTAGAAGCTGAAAACCTCA
AGGCACAAGCTACTCGTGATGAAGATTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCCAAATACAAAGAAATGCAG
CAAAATAAAATGGCTGATCAAGATACGCCTCTTATCAGTGAAAAAACCATTGAACATATCATTGAGCAAAAGACAAATAT
TCCAGTTGGCGACTTGAAAGAAAAGGAACAATCACAATTGATTAGTCTGGCTGATGATTTGAAAGCTCATGTCATTGGTC
AAGATGATGCTGTTGATAAAATTGCGAAGGCCATTCGCCGTAATCGAGTTGGACTAGGTACACCAGACCGACCAATTGGT
TCTTTCCTTTTTGTTGGACCAACCGGTGTCGGCAAAACAGAACTTTCTAAACAACTAGCGATTGAGCTCTTTGGTTCAGC
TGACAGCATGATTCGTTTTGATATGAGTGAGTATATGGAAAAACATAGCGTAGCAAAACTCGTCGGAGCGCCTCCAGGTT
ACGTTGGCTACGAAGAAGCTGGACAATTAACAGAACGTGTACGTCGTAATCCTTATTCTCTCATTTTACTTGATGAAATA
GAAAAAGCTCACCCAGATGTCATGCATATGTTCTTGCAAGTACTTGATGACGGACGTCTGACAGATGGACAAGGTCGGAC
AGTCAATTTCAAAGATACGATTATCATTATGACTTCCAACGCCGGTACTGGAAAAGTCGAAGCAAACGTTGGATTTGGTG
CAGCGCGTGAAGGACGAACCAATTCCGTCCTCAGTGAATTGGGCAACTTCTTCAGCCCAGAATTTATAAATCGTTTCGAT
GGTATTATTGAGTTCAAATCTCTTAGCAAGGAAAATCTCCTACAAATCGTAGATTTGATGCTTGAAGATGTGAATAAACG
CTTAGCTGTAAATGGTATTCACCTAGACGTAACAGACAAAGTCAAGGAAAAATTAGTTAATCTTGGTTACGATCCAAAAA
TGGGAGCTCGTCCACTTCGTCGGACAATCCAAGATCACATCGAGGATGCTATCACCGACTACTATCTTGAACATCCAAGC
GAAAAAGAGCTCAAAGCTGTCATGACGAGCAATAGCAAGATTGTTATCAAGTCGTCCAAAAAGTCTGAAAACGAGACCGA
AAAAGAAATTAAAACAACAGCAGACGACACTGCTAACTGA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(648-722)

AAA lid domain (AAA_lid_9)

(292-389)

ATPase family associated with various cellular activities (AAA) (AAA)

(154-273)

AAA domain (Cdc48 subfamily) (AAA_2)

(477-640)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9P735

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.569

99.078

0.858
  clpE Streptococcus pneumoniae D39

86.569

99.078

0.858
  clpE Streptococcus pneumoniae R6

86.569

99.078

0.858
  clpE Streptococcus pneumoniae TIGR4

86.569

99.078

0.858
  clpE Streptococcus mutans UA159

84.19

100

0.842
  clpC Lactococcus lactis subsp. cremoris KW2

75.958

99.736

0.758
  clpC Bacillus subtilis subsp. subtilis str. 168

50

91.963

0.46
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.546

85.903

0.408
  clpC Streptococcus pneumoniae Rx1

48.553

81.95

0.398
  clpC Streptococcus pneumoniae D39

48.553

81.95

0.398
  clpC Streptococcus pneumoniae TIGR4

48.392

81.95

0.397
  clpC Streptococcus mutans UA159

47.436

82.213

0.39
  clpC Streptococcus thermophilus LMD-9

47.352

82.082

0.389
  clpC Streptococcus thermophilus LMG 18311

47.276

82.213

0.389

Multiple sequence alignment