Detailed information NTG0061442

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: SCRE_RS00675
• Genome accession: NC_022236
• Coordinates: 123633..126062 (+)
• Length: 809 a.a.
• NCBI ID: WP_006269148.1
• Uniprot ID: F9P9P2
• Organism: Streptococcus constellatus subsp. pharyngis C232
• Function: degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 118633..131062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCRE_RS00645 (SCRE_0127)	-	119145..119930 (+)	786	WP_006269131.1	hypothetical protein	-
SCRE_RS00655 (SCRE_0129)	rpsB	120573..121355 (+)	783	WP_003071092.1	30S ribosomal protein S2	-
SCRE_RS00660 (SCRE_0130)	tsf	121439..122482 (+)	1044	WP_006269216.1	translation elongation factor Ts	-
SCRE_RS00665 (SCRE_0131)	-	122559..122909 (-)	351	WP_003074775.1	hypothetical protein	-
SCRE_RS00670 (SCRE_0132)	-	123168..123629 (+)	462	WP_009567829.1	CtsR family transcriptional regulator	-
SCRE_RS00675 (SCRE_0133)	clpC	123633..126062 (+)	2430	WP_006269148.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SCRE_RS00680 (SCRE_0134)	-	126109..126549 (+)	441	WP_006269160.1	GNAT family N-acetyltransferase	-
SCRE_RS00685 (SCRE_0135)	dusB	126620..127591 (-)	972	WP_020997545.1	tRNA dihydrouridine synthase DusB	-
SCRE_RS00690 (SCRE_0136)	hslO	127578..128450 (-)	873	WP_006268912.1	Hsp33 family molecular chaperone HslO	-
SCRE_RS00695 (SCRE_0137)	-	128658..129928 (-)	1271	Protein_121	toxic anion resistance protein	-
SCRE_RS00700 (SCRE_0138)	-	129947..130765 (-)	819	WP_020997547.1	hypothetical protein	-

Sequence

Protein

• Length: 809 a.a.
• Molecular weight: 89953.22 Da
• Isoelectric Point: 6.4079

>NTDB_id=61442 SCRE_RS00675 WP_006269148.1 123633..126062(+) (clpC) [Streptococcus constellatus subsp. pharyngis C232]
MKHSKALTESIESAQLLASHFETDYLESWQLLIAMANNPYSVAGSVLNDYPLEIDDFEKAAFHITGKVYQQEGDFTIWPF
SYRMKVLFLTAEQIAGAVHANNLGTEHVLLAMLFDRGSLAARILEFIGFSYEDKEGVLRMTDLRKNLEHKASWNKEDLKA
IRHLNKSAAATRQTMANMMGMHPATSGGLEDYTRDLTEMAHMGLLEPVIGRDKEISRMLQILSRKTKNNPVLVGDAGVGK
TALALGLAQRVAAGQVPNELAKMRVLELDLMNVVAGTRFRGDFEERMNNIINDIEADGHVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKYIEKDAALSRRFAKVAIEEPTVADSIAILQGLKKTYEDHHKVVITDSAIET
AVKYAHRYLTGKHLPDSAIDLLDEAAATVQNKGPQNHVKVELSAADEALMAGNWNKVSTLLEKESQPIVYKLRVKDEDVL
ATLSSLSGIPVQKLTQTDAKKYLNLEKELHKRVIGQNEAISAISRAIRRNQSGIRTSKRPIGSFMFLGPTGVGKTELAKA
LAEVLFDDETALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNRPYSVLLFDEVEKAHPDIFNVLLQVLDDG
VLTDSKGRKVDFSNTIIIMTSNLGATSLRDDKTVGFGARDVRFDHENMEKRMMEELKKAYRPEFINRIDEKVVFHSLTSE
DMQEVVKIMVQPLISSLAEKGIKLKFQPSALKLLAQEGYDPEMGARPLRRILQTRVEDHLSELLLAGELKTGQSLKVGVK
AGKLKFEVL

Nucleotide

• Length: 2430 bp

>NTDB_id=61442 SCRE_RS00675 WP_006269148.1 123633..126062(+) (clpC) [Streptococcus constellatus subsp. pharyngis C232]
ATGAAACATTCAAAAGCTTTGACAGAAAGTATTGAATCAGCACAGTTATTAGCAAGTCATTTTGAAACGGATTATTTAGA
GTCTTGGCAGCTGTTGATTGCTATGGCAAATAATCCTTATAGTGTTGCTGGTTCAGTTTTAAATGATTACCCACTTGAAA
TTGATGATTTTGAAAAGGCAGCTTTTCATATCACGGGGAAAGTCTATCAACAAGAGGGAGACTTTACTATTTGGCCGTTT
TCTTATCGCATGAAAGTGCTATTTTTGACTGCTGAACAAATTGCAGGGGCGGTTCATGCTAATAATCTTGGGACAGAGCA
TGTATTGCTAGCTATGTTATTTGACCGAGGAAGCTTGGCAGCGCGTATTCTTGAATTTATTGGTTTTAGTTACGAAGATA
AAGAAGGCGTTTTGCGCATGACAGATCTGCGGAAAAATTTAGAGCATAAGGCCAGCTGGAATAAAGAGGATTTAAAGGCT
ATTCGTCACCTAAATAAAAGTGCTGCAGCAACAAGACAAACGATGGCTAATATGATGGGAATGCATCCTGCAACCAGTGG
CGGACTAGAAGATTATACTCGTGATCTAACTGAAATGGCTCATATGGGCCTTTTAGAACCGGTCATTGGGCGGGATAAAG
AGATTTCTCGCATGCTTCAGATTTTAAGTCGCAAGACGAAAAATAATCCAGTTTTGGTAGGAGATGCAGGAGTTGGGAAG
ACAGCATTAGCCCTTGGTTTGGCGCAACGTGTGGCAGCTGGTCAAGTTCCAAATGAGCTTGCAAAGATGAGAGTTTTAGA
GCTAGATTTAATGAATGTGGTGGCTGGAACTCGTTTTCGTGGTGATTTTGAGGAACGGATGAACAATATTATCAATGATA
TTGAAGCAGATGGACATGTCATTCTTTTCATTGATGAGCTTCATACTATTATGGGGTCGGGTAGCGGGATTGACTCGACA
TTAGATGCAGCGAACATTCTCAAGCCAGCTTTGGCCAGAGGGACACTCAGAACGGTCGGCGCAACGACACAAGAAGAGTA
CCAGAAATATATTGAAAAGGACGCAGCTCTTTCACGGCGCTTTGCCAAGGTTGCTATTGAAGAGCCAACAGTAGCTGATA
GTATTGCGATTTTACAAGGGCTAAAGAAAACTTATGAAGATCACCACAAGGTCGTGATTACGGATTCGGCCATTGAGACG
GCTGTTAAGTATGCTCATCGTTATCTAACAGGCAAACATCTACCGGATTCGGCCATTGATTTGCTAGATGAAGCTGCTGC
AACAGTACAAAATAAAGGTCCGCAAAATCACGTAAAAGTCGAATTGAGTGCAGCAGACGAGGCTTTAATGGCAGGCAATT
GGAACAAAGTTAGTACGTTGTTGGAGAAAGAGAGTCAGCCGATTGTCTATAAATTAAGAGTGAAAGACGAGGATGTTTTG
GCAACGCTCAGCAGTTTATCAGGTATTCCCGTGCAAAAGTTGACGCAAACAGATGCGAAGAAATACCTCAATTTAGAAAA
GGAACTGCACAAGCGGGTCATTGGGCAAAATGAAGCAATTTCTGCTATTAGTCGAGCGATTCGGCGCAATCAATCCGGTA
TCCGCACTAGCAAGCGTCCAATTGGCTCCTTTATGTTCTTAGGGCCAACCGGGGTCGGAAAAACTGAGCTAGCTAAGGCT
TTGGCAGAAGTTCTCTTTGATGACGAAACAGCACTGATTCGTTTTGATATGAGTGAATACATGGAAAAATTTGCTGCCAG
TCGCCTCAATGGAGCGCCTCCAGGTTATGTTGGTTATGAAGAAGGGGGCGAATTGACTGAAAAAGTTCGCAATCGTCCGT
ACTCTGTGCTCCTCTTTGATGAGGTAGAAAAAGCTCATCCTGATATTTTCAATGTGCTTCTCCAAGTCTTAGATGACGGG
GTGCTGACAGACAGCAAGGGGCGTAAGGTGGATTTTTCCAATACCATTATCATTATGACCAGCAATCTTGGTGCGACAAG
TTTACGGGACGACAAGACGGTTGGGTTCGGAGCAAGAGATGTTCGTTTTGATCATGAAAATATGGAAAAACGAATGATGG
AAGAGCTAAAGAAAGCTTATCGTCCAGAATTTATTAACCGAATTGATGAAAAGGTTGTTTTTCACAGTTTGACTAGCGAA
GACATGCAGGAAGTAGTGAAAATTATGGTGCAACCGCTCATTTCTAGTCTTGCAGAAAAAGGAATTAAACTCAAATTCCA
GCCGAGTGCTTTGAAGCTTCTAGCTCAAGAGGGCTATGATCCTGAAATGGGAGCTCGTCCATTGCGTCGAATTCTACAAA
CTCGGGTGGAAGACCATTTATCAGAATTACTTTTAGCAGGTGAGCTAAAAACGGGACAAAGCTTAAAAGTCGGTGTCAAG
GCTGGAAAATTGAAGTTTGAAGTGCTCTGA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (371-441)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (91-133)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-60)

• AAA domain (Cdc48 subfamily) (AAA_2) (539-710)

• ATPase family associated with various cellular activities (AAA) (AAA) (231-347)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (717-797)

3D structure

• AlphaFold DB: F9P9P2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae TIGR4	77.189	100	0.774
clpC	Streptococcus pneumoniae Rx1	77.189	100	0.774
clpC	Streptococcus pneumoniae D39	77.189	100	0.774
clpC	Streptococcus mutans UA159	66.135	100	0.666
clpC	Streptococcus thermophilus LMG 18311	65.111	100	0.655
clpC	Streptococcus thermophilus LMD-9	64.988	100	0.654
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.76	100	0.512
clpC	Bacillus subtilis subsp. subtilis str. 168	45.693	99.011	0.452