Detailed information NTG0613725

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LD199_RS03420
• Genome accession: NZ_CP084878
• Coordinates: 717690..718733 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GS426
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 712690..723733

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LD199_RS03390 (LD199_03390)	-	713116..713226 (+)	111	WP_001790257.1	hypothetical protein	-
LD199_RS03395 (LD199_03395)	-	713255..713668 (+)	414	WP_001557448.1	hypothetical protein	-
LD199_RS03400 (LD199_03400)	-	714099..715085 (-)	987	WP_000999717.1	FUSC family protein	-
LD199_RS03405 (LD199_03405)	map	715616..716374 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LD199_RS03410 (LD199_03410)	-	716591..716977 (+)	387	WP_001110179.1	hypothetical protein	-
LD199_RS03415 (LD199_03415)	liaF	716992..717693 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LD199_RS03420 (LD199_03420)	vraS	717690..718733 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LD199_RS03425 (LD199_03425)	vraR	718723..719352 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LD199_RS03430 (LD199_03430)	-	719465..720682 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
LD199_RS03435 (LD199_03435)	-	720960..721235 (-)	276	WP_117195002.1	YtxH domain-containing protein	-
LD199_RS03440 (LD199_03440)	-	721242..721706 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LD199_RS03445 (LD199_03445)	-	721853..722053 (+)	201	WP_000180460.1	DUF1128 family protein	-
LD199_RS03450 (LD199_03450)	-	722056..723312 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=613725 LD199_RS03420 WP_001017131.1 717690..718733(+) (vraS) [Staphylococcus aureus strain GS426]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=613725 LD199_RS03420 WP_001017131.1 717690..718733(+) (vraS) [Staphylococcus aureus strain GS426]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1