Detailed information NTG0611410

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LFR23_RS09305
• Genome accession: NZ_CP084480
• Coordinates: 1951194..1952237 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain RMLUG1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1946194..1957237

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LFR23_RS09280 (LFR23_09275)	-	1946484..1947845 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
LFR23_RS09285 (LFR23_09280)	-	1947979..1948959 (-)	981	WP_002492696.1	FUSC family protein	-
LFR23_RS09290 (LFR23_09285)	map	1949204..1949959 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
LFR23_RS09295 (LFR23_09290)	-	1950085..1950471 (+)	387	WP_002477960.1	hypothetical protein	-
LFR23_RS09300 (LFR23_09295)	liaF	1950496..1951197 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
LFR23_RS09305 (LFR23_09300)	vraS	1951194..1952237 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
LFR23_RS09310 (LFR23_09305)	vraR	1952227..1952856 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
LFR23_RS09315 (LFR23_09310)	-	1953029..1954258 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
LFR23_RS09320 (LFR23_09315)	-	1954461..1954745 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
LFR23_RS09325 (LFR23_09320)	-	1954752..1955216 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
LFR23_RS09330 (LFR23_09325)	-	1955380..1955565 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
LFR23_RS09335 (LFR23_09330)	-	1955635..1956816 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=611410 LFR23_RS09305 WP_002461334.1 1951194..1952237(+) (vraS) [Staphylococcus lugdunensis strain RMLUG1]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=611410 LFR23_RS09305 WP_002461334.1 1951194..1952237(+) (vraS) [Staphylococcus lugdunensis strain RMLUG1]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911