Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LE166_RS10200 Genome accession   NZ_CP084437
Coordinates   2094070..2095434 (-) Length   454 a.a.
NCBI ID   WP_267262442.1    Uniprot ID   -
Organism   Staphylococcus lugdunensis strain RMLUG3     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2085690..2099495 2094070..2095434 within 0


Gene organization within MGE regions


Location: 2085690..2099495
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LE166_RS10160 (LE166_10175) mecA 2085690..2087699 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  LE166_RS10165 (LE166_10180) - 2087796..2088782 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  LE166_RS10170 (LE166_10185) - 2088754..2089014 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  LE166_RS10175 (LE166_10190) - 2089005..2090612 (-) 1608 Protein_1954 IS1182 family transposase -
  LE166_RS10180 (LE166_10195) - 2090664..2091170 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  LE166_RS10185 (LE166_10200) - 2091185..2091496 (-) 312 WP_000700851.1 DUF960 family protein -
  LE166_RS10190 (LE166_10205) - 2091583..2091933 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LE166_RS10195 (LE166_10210) ccrB 2092455..2094083 (-) 1629 WP_252305134.1 recombinase family protein Machinery gene
  LE166_RS10200 (LE166_10215) ccrA 2094070..2095434 (-) 1365 WP_267262442.1 recombinase family protein Machinery gene
  LE166_RS10205 (LE166_10220) - 2095668..2097455 (-) 1788 WP_001573627.1 DUF927 domain-containing protein -
  LE166_RS10210 (LE166_10225) - 2097455..2097769 (-) 315 WP_001573626.1 hypothetical protein -

Sequence

Protein


Download         Length: 454 a.a.        Molecular weight: 53348.13 Da        Isoelectric Point: 9.9596

>NTDB_id=611291 LE166_RS10200 WP_267262442.1 2094070..2095434(-) (ccrA) [Staphylococcus lugdunensis strain RMLUG3]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQNTIQ
NIIQKRFTLNMLYPYIDEILITKSKTLMGIYFKNEPLNIVNCINEERMKHNATT

Nucleotide


Download         Length: 1365 bp        

>NTDB_id=611291 LE166_RS10200 WP_267262442.1 2094070..2095434(-) (ccrA) [Staphylococcus lugdunensis strain RMLUG3]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTGCATGATGGTTATTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATTATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAAAACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATGCTGTATCCCTACATTGATGAAATTCTTATCACAAAAAGTAAAACACT
AATGGGTATCTATTTCAAAAATGAACCCTTAAACATCGTCAATTGCATAAATGAAGAAAGGATGAAACATAATGCAACAA
CTTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

95.918

97.137

0.932
  ccrA Staphylococcus aureus COL

76.591

96.916

0.742