Detailed information NTG0611263

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LE166_RS02810
• Genome accession: NZ_CP084437
• Coordinates: 567505..568548 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain RMLUG3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 562505..573548

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LE166_RS02785 (LE166_02785)	-	562795..564156 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
LE166_RS02790 (LE166_02790)	-	564290..565270 (-)	981	WP_002492696.1	aromatic acid exporter family protein	-
LE166_RS02795 (LE166_02795)	map	565515..566270 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
LE166_RS02800 (LE166_02800)	-	566396..566782 (+)	387	WP_002477960.1	hypothetical protein	-
LE166_RS02805 (LE166_02805)	liaF	566807..567508 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
LE166_RS02810 (LE166_02810)	vraS	567505..568548 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
LE166_RS02815 (LE166_02815)	vraR	568538..569167 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
LE166_RS02820 (LE166_02820)	-	569340..570569 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
LE166_RS02825 (LE166_02825)	-	570772..571056 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
LE166_RS02830 (LE166_02830)	-	571063..571527 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
LE166_RS02835 (LE166_02835)	-	571691..571876 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
LE166_RS02840 (LE166_02840)	-	571946..573127 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=611263 LE166_RS02810 WP_002461334.1 567505..568548(+) (vraS) [Staphylococcus lugdunensis strain RMLUG3]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=611263 LE166_RS02810 WP_002461334.1 567505..568548(+) (vraS) [Staphylococcus lugdunensis strain RMLUG3]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911