Detailed information NTG0611241

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LE165_RS03025
• Genome accession: NZ_CP084434
• Coordinates: 610134..611177 (-)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain RMLUG2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 605134..616177

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LE165_RS02995 (LE165_03010)	-	605555..606736 (-)	1182	WP_235605807.1	aminopeptidase	-
LE165_RS03000 (LE165_03015)	-	606806..606991 (-)	186	WP_002492715.1	DUF1128 domain-containing protein	-
LE165_RS03005 (LE165_03020)	-	607155..607619 (+)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
LE165_RS03010 (LE165_03025)	-	607626..607910 (+)	285	WP_002461330.1	YtxH domain-containing protein	-
LE165_RS03015 (LE165_03030)	-	608113..609342 (+)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
LE165_RS03020 (LE165_03035)	vraR	609515..610144 (-)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
LE165_RS03025 (LE165_03040)	vraS	610134..611177 (-)	1044	WP_002461334.1	sensor histidine kinase	Regulator
LE165_RS03030 (LE165_03045)	liaF	611174..611875 (-)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
LE165_RS03035 (LE165_03050)	-	611900..612286 (-)	387	WP_002477960.1	hypothetical protein	-
LE165_RS03040 (LE165_03055)	map	612412..613167 (-)	756	WP_002461338.1	type I methionyl aminopeptidase	-
LE165_RS03045 (LE165_03060)	-	613412..614392 (+)	981	WP_002492696.1	FUSC family protein	-
LE165_RS03050 (LE165_03065)	-	614526..615887 (+)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=611241 LE165_RS03025 WP_002461334.1 610134..611177(-) (vraS) [Staphylococcus lugdunensis strain RMLUG2]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=611241 LE165_RS03025 WP_002461334.1 610134..611177(-) (vraS) [Staphylococcus lugdunensis strain RMLUG2]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911