Detailed information NTG0607241

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: K3A99_RS09520
• Genome accession: NZ_CP083671
• Coordinates: 1946069..1947112 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain HL25870
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1941069..1952112

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K3A99_RS09490 (K3A99_001878)	-	1941490..1942746 (-)	1257	WP_001793428.1	aminopeptidase	-
K3A99_RS09495 (K3A99_001879)	-	1942749..1942949 (-)	201	WP_000180460.1	DUF1128 family protein	-
K3A99_RS09500 (K3A99_001880)	-	1943096..1943560 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
K3A99_RS09505 (K3A99_001881)	-	1943567..1943842 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
K3A99_RS09510 (K3A99_001882)	-	1944120..1945337 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
K3A99_RS09515 (K3A99_001883)	vraR	1945450..1946079 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
K3A99_RS09520 (K3A99_001884)	vraS	1946069..1947112 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
K3A99_RS09525 (K3A99_001885)	liaF	1947109..1947810 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
K3A99_RS09530 (K3A99_001886)	-	1947825..1948211 (-)	387	WP_001110182.1	hypothetical protein	-
K3A99_RS09535 (K3A99_001887)	map	1948428..1949186 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
K3A99_RS09540 (K3A99_001888)	-	1949770..1950756 (+)	987	WP_000999712.1	FUSC family protein	-
K3A99_RS09545 (K3A99_001889)	-	1950945..1951358 (-)	414	WP_025174370.1	hypothetical protein	-
K3A99_RS09550 (K3A99_001890)	-	1951387..1951497 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=607241 K3A99_RS09520 WP_001017131.1 1946069..1947112(-) (vraS) [Staphylococcus aureus strain HL25870]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=607241 K3A99_RS09520 WP_001017131.1 1946069..1947112(-) (vraS) [Staphylococcus aureus strain HL25870]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1