Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   K748_RS00185 Genome accession   NC_021882
Coordinates   30329..32113 (+) Length   594 a.a.
NCBI ID   WP_015645212.1    Uniprot ID   -
Organism   Helicobacter pylori UM298     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 25329..37113
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K748_RS00155 (K748_01380) motB 25985..26752 (+) 768 WP_015645208.1 flagellar motor protein MotB -
  K748_RS00160 (K748_01385) - 26756..27193 (+) 438 WP_001031792.1 hypothetical protein -
  K748_RS00165 (K748_01390) - 27378..29039 (+) 1662 WP_015645209.1 ABC transporter permease/substrate-binding protein -
  K748_RS00170 (K748_01395) - 29043..29684 (+) 642 WP_015645210.1 ATP-binding cassette domain-containing protein -
  K748_RS00175 (K748_08175) - 29696..29875 (-) 180 WP_000468796.1 hypothetical protein -
  K748_RS00180 (K748_01405) - 29867..30328 (+) 462 WP_000437191.1 hypothetical protein -
  K748_RS00185 (K748_01410) uvrC 30329..32113 (+) 1785 WP_015645212.1 excinuclease ABC subunit UvrC Machinery gene
  K748_RS00190 (K748_01415) - 32124..33389 (+) 1266 WP_015645213.1 homoserine dehydrogenase -
  K748_RS00195 (K748_01420) - 33390..33734 (+) 345 WP_001211660.1 YraN family protein -
  K748_RS00200 (K748_01425) trxA 33823..34143 (+) 321 WP_000020200.1 thioredoxin -
  K748_RS00205 (K748_01430) trxB 34149..35084 (+) 936 WP_015645214.1 thioredoxin-disulfide reductase -
  K748_RS00210 (K748_01435) - 35247..36068 (+) 822 WP_015645215.1 glycosyltransferase family 25 protein -
  K748_RS00215 (K748_01440) - 36263..36511 (-) 249 WP_015645216.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68736.03 Da        Isoelectric Point: 9.6229

>NTDB_id=60657 K748_RS00185 WP_015645212.1 30329..32113(+) (uvrC) [Helicobacter pylori UM298]
MADLLSSLKNLSHSSGVYQYFDKNHQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFICMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDV
SHHANSQCVGGMVVYENHEFQKNSYRRYHLKGSNEYAQMSELLTRRALDFNKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTASDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=60657 K748_RS00185 WP_015645212.1 30329..32113(+) (uvrC) [Helicobacter pylori UM298]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCACCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGTTATTTTTCTATCCACAATAATGAAATCACGCCTA
ACCATCGCACCAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAACAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTGAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGACATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTCCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACTAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCATTTGCATGGATTTGGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTGGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTCAATGGGTTTGACA
CCGATGAAGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATGCCTGAACAGATCTTATTGAGT
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATCTCCCATCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAGGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGATGTA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATCATGAATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTAATAAAGAGC
CACCGCCTAATTTATGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATCAT
CCACACCGCTAGCGATACTTTTAAATTGCTCCCCAGCGACAAGCGCTTGCAGTGGGTTCAAAAATTGCGCGATGAAAGCC
ACCGATATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCTAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAAGAAAAAAA
CGCTGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.97

100

0.97

Multiple sequence alignment