Detailed information NTG0605747

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LAE57_RS13015
• Genome accession: NZ_CP083434
• Coordinates: 2699214..2700257 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain DC.RB_015
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2694214..2705257

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LAE57_RS12985 (LAE57_12950)	-	2694640..2694750 (+)	111	WP_001790257.1	hypothetical protein	-
LAE57_RS12990 (LAE57_12955)	-	2694779..2695192 (+)	414	WP_025174552.1	hypothetical protein	-
LAE57_RS12995 (LAE57_12960)	-	2695625..2696611 (-)	987	WP_000999708.1	FUSC family protein	-
LAE57_RS13000 (LAE57_12965)	map	2697140..2697898 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LAE57_RS13005 (LAE57_12970)	-	2698115..2698501 (+)	387	WP_111058724.1	hypothetical protein	-
LAE57_RS13010 (LAE57_12975)	liaF	2698516..2699217 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LAE57_RS13015 (LAE57_12980)	vraS	2699214..2700257 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LAE57_RS13020 (LAE57_12985)	vraR	2700247..2700876 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
LAE57_RS13025 (LAE57_12990)	-	2700989..2702206 (-)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
LAE57_RS13030 (LAE57_12995)	-	2702484..2702759 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LAE57_RS13035 (LAE57_13000)	-	2702766..2703230 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LAE57_RS13040 (LAE57_13005)	-	2703377..2703577 (+)	201	WP_000180460.1	DUF1128 family protein	-
LAE57_RS13045 (LAE57_13010)	-	2703580..2704836 (+)	1257	WP_078065149.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=605747 LAE57_RS13015 WP_001017131.1 2699214..2700257(+) (vraS) [Staphylococcus aureus strain DC.RB_015]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=605747 LAE57_RS13015 WP_001017131.1 2699214..2700257(+) (vraS) [Staphylococcus aureus strain DC.RB_015]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1