Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   LAE57_RS12645 Genome accession   NZ_CP083434
Coordinates   2625311..2626027 (-) Length   238 a.a.
NCBI ID   WP_000688492.1    Uniprot ID   A0A7U7IEW1
Organism   Staphylococcus aureus strain DC.RB_015     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2620311..2631027
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LAE57_RS12625 (LAE57_12590) - 2621405..2622355 (+) 951 WP_000790321.1 LacI family DNA-binding transcriptional regulator -
  LAE57_RS12630 (LAE57_12595) - 2622504..2623988 (+) 1485 WP_000141422.1 sucrose-6-phosphate hydrolase -
  LAE57_RS12635 (LAE57_12600) - 2623985..2624944 (+) 960 WP_001253300.1 carbohydrate kinase family protein -
  LAE57_RS12640 (LAE57_12605) - 2625132..2625239 (-) 108 WP_031844951.1 hypothetical protein -
  LAE57_RS12645 (LAE57_12610) agrA 2625311..2626027 (-) 717 WP_000688492.1 quorum-sensing response regulator AgrA Regulator
  LAE57_RS12650 (LAE57_12615) agrC 2626046..2627338 (-) 1293 WP_031844950.1 quorum-sensing sensor histidine kinase AgrC -
  LAE57_RS12655 (LAE57_12620) agrD 2627363..2627503 (-) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  LAE57_RS12660 (LAE57_12625) agrB 2627500..2628069 (-) 570 WP_001105712.1 accessory gene regulator AgrB -
  LAE57_RS13885 hld 2628359..2628439 (+) 81 WP_000046023.1 delta-hemolysin -
  LAE57_RS12670 (LAE57_12635) - 2629038..2629823 (-) 786 WP_000867953.1 carbon-nitrogen family hydrolase -
  LAE57_RS12675 (LAE57_12640) - 2630184..2630810 (-) 627 WP_000522383.1 nitroreductase family protein -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27905.90 Da        Isoelectric Point: 6.0927

>NTDB_id=605746 LAE57_RS12645 WP_000688492.1 2625311..2626027(-) (agrA) [Staphylococcus aureus strain DC.RB_015]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=605746 LAE57_RS12645 WP_000688492.1 2625311..2626027(-) (agrA) [Staphylococcus aureus strain DC.RB_015]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGATCCA
GTTGGTAACATTATATTTGTTACGAGTCACAGTGAACTTACCTATTTAACGTTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCTGAATTAAGAACTCGAATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTGT
TGTCTAAAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-120)

LytTr DNA-binding domain (LytTR)

(151-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7IEW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

100

100

1