Detailed information NTG0605143

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: K3A98_RS04800
• Genome accession: NZ_CP083259
• Coordinates: 946154..947197 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017129.1
• Uniprot ID: A0A0U1MRG1
• Organism: Staphylococcus aureus strain HL25274
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 941154..952197

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K3A98_RS04770 (K3A98_000946)	-	941721..941830 (+)	110	Protein_939	hypothetical protein	-
K3A98_RS04775 (K3A98_000947)	-	941859..942275 (+)	417	WP_025174454.1	hypothetical protein	-
K3A98_RS04780 (K3A98_000948)	-	942451..943437 (-)	987	WP_000999711.1	FUSC family protein	-
K3A98_RS04785 (K3A98_000949)	map	944080..944838 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
K3A98_RS04790 (K3A98_000950)	-	945055..945441 (+)	387	WP_001110183.1	hypothetical protein	-
K3A98_RS04795 (K3A98_000951)	liaF	945456..946157 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
K3A98_RS04800 (K3A98_000952)	vraS	946154..947197 (+)	1044	WP_001017129.1	sensor histidine kinase	Regulator
K3A98_RS04805 (K3A98_000953)	vraR	947187..947816 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
K3A98_RS04810 (K3A98_000954)	-	947929..949146 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
K3A98_RS04815 (K3A98_000955)	-	949424..949699 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
K3A98_RS04820 (K3A98_000956)	-	949706..950170 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
K3A98_RS04825 (K3A98_000957)	-	950317..950517 (+)	201	WP_001813025.1	DUF1128 family protein	-
K3A98_RS04830 (K3A98_000958)	-	950520..951776 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40060.56 Da
• Isoelectric Point: 6.0577

>NTDB_id=605143 K3A98_RS04800 WP_001017129.1 946154..947197(+) (vraS) [Staphylococcus aureus strain HL25274]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQILILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=605143 K3A98_RS04800 WP_001017129.1 946154..947197(+) (vraS) [Staphylococcus aureus strain HL25274]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCT
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCGAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0U1MRG1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997