Detailed information NTG0601574

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: K7H07_RS04635
• Genome accession: NZ_CP082336
• Coordinates: 974197..975240 (+)
• Length: 347 a.a.
• NCBI ID: WP_002509180.1
• Uniprot ID: A0A7V7SQH4
• Organism: Staphylococcus arlettae strain AHKW2e
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 969197..980240

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K7H07_RS04610 (K7H07_04610)	-	969877..970602 (+)	726	WP_222985253.1	type 1 glutamine amidotransferase	-
K7H07_RS04615 (K7H07_04615)	-	971089..972075 (-)	987	WP_103388397.1	FUSC family protein	-
K7H07_RS04620 (K7H07_04620)	map	972241..972993 (+)	753	WP_021459027.1	type I methionyl aminopeptidase	-
K7H07_RS04625 (K7H07_04625)	-	973096..973482 (+)	387	WP_002509178.1	hypothetical protein	-
K7H07_RS04630 (K7H07_04630)	liaF	973499..974200 (+)	702	WP_002509179.1	cell wall-active antibiotics response protein LiaF	-
K7H07_RS04635 (K7H07_04635)	vraS	974197..975240 (+)	1044	WP_002509180.1	sensor histidine kinase	Regulator
K7H07_RS04640 (K7H07_04640)	vraR	975230..975859 (+)	630	WP_002509181.1	response regulator transcription factor	Regulator
K7H07_RS04645 (K7H07_04645)	-	975920..976999 (-)	1080	WP_021459026.1	YihY/virulence factor BrkB family protein	-
K7H07_RS04650 (K7H07_04650)	-	977279..977563 (-)	285	WP_002509183.1	hypothetical protein	-
K7H07_RS04655 (K7H07_04655)	-	977570..978034 (-)	465	WP_002509184.1	low molecular weight protein-tyrosine-phosphatase	-
K7H07_RS04660 (K7H07_04660)	-	978170..978373 (+)	204	WP_021459025.1	DUF1128 family protein	-
K7H07_RS04665 (K7H07_04665)	-	978385..979623 (+)	1239	WP_021459024.1	aminopeptidase	-
K7H07_RS04670 (K7H07_04670)	-	979657..980184 (+)	528	Protein_921	acyl-CoA thioesterase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39859.16 Da
• Isoelectric Point: 5.2631

>NTDB_id=601574 K7H07_RS04635 WP_002509180.1 974197..975240(+) (vraS) [Staphylococcus arlettae strain AHKW2e]
MNHYIRAIGSMLILVYSTLIAFFFIDKIFVNIMYFQGMFYTQIFGIPVFLFLNLLIILLCIIVGSVLAYKINQQNHWLQT
QIERSIEGETVGINDQDIELYNETIELYQTLVPLNQEVHKLRMKTQNLTNESYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESQLTPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVVDLQKKVPMKVIHDI
EDFTVPKGIEDHLFRITQEAISNTLRHSNGTKVTIELFNQEAYLLLRIQDNGIGFNVDDKAEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLDKEDIDAN

Nucleotide

• Length: 1044 bp

>NTDB_id=601574 K7H07_RS04635 WP_002509180.1 974197..975240(+) (vraS) [Staphylococcus arlettae strain AHKW2e]
ATGAATCACTACATTAGAGCAATAGGCTCTATGCTAATATTAGTATATAGTACATTAATTGCTTTTTTCTTTATAGATAA
AATATTTGTAAATATTATGTATTTTCAAGGTATGTTTTATACCCAAATATTTGGTATTCCAGTATTTTTATTTTTAAATT
TGCTCATAATTTTATTATGTATCATTGTAGGATCGGTTTTAGCTTATAAAATAAACCAGCAAAACCATTGGCTACAAACA
CAAATTGAACGTTCAATTGAAGGAGAAACAGTAGGGATTAATGACCAAGATATAGAACTTTATAATGAAACTATAGAGCT
CTATCAAACGTTAGTTCCACTCAATCAAGAAGTACATAAACTGCGAATGAAGACCCAAAATTTAACAAATGAATCTTATA
ATTTAAACGATGTCAAAGTTAAAAAAATAATCGAAGATGAACGACAAAGATTGGCTAGGGAATTACATGATTCAGTGAGT
CAGCAACTTTTTGCAGCTAGCATGATGTTATCAGCTATCAAAGAATCTCAATTAACACCACCTTTAGATCAACAAATCCC
TACATTAGAAAAAATGGTACAAGATTCTCAACTAGAAATGAGAGCATTATTACTACATTTAAGACCAATTGGTTTAAAAG
ATAAGTCTCTCGGAGAAGGTATTAAAGATTTAGTTGTCGATTTACAGAAAAAAGTACCAATGAAGGTCATACATGACATT
GAAGATTTTACTGTACCTAAAGGTATTGAAGATCATTTGTTTCGTATTACGCAAGAAGCGATATCCAATACATTACGTCA
TTCCAACGGTACAAAAGTAACAATTGAATTATTTAATCAAGAAGCATATTTATTATTACGTATTCAAGATAACGGTATTG
GTTTTAACGTAGATGATAAAGCTGAACAAAGTTATGGATTGAAAAATATGCGGGAGCGTGCATTAGAAATAGGTGCCACA
TTCCATATTGTATCGCTGCCTGATTCAGGTACTAGAATAGAAGTGAAAGCACCATTAGATAAGGAGGATATAGATGCCAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A7V7SQH4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	88.63	98.847	0.876