Detailed information NTG0059939

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: L897_RS06135
• Genome accession: NC_021807
• Coordinates: 1208228..1209265 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes HSC5
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1203228..1214265

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L897_RS06110 (L897_06285)	-	1203232..1203759 (-)	528	WP_002983837.1	Dps family protein	-
L897_RS06115 (L897_06290)	-	1203987..1204613 (+)	627	WP_002983834.1	A24 family peptidase	-
L897_RS06120 (L897_06295)	rlmN	1204695..1205774 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
L897_RS06125 (L897_06300)	-	1205778..1206398 (-)	621	WP_002992791.1	YutD family protein	-
L897_RS06130 (L897_06305)	-	1206846..1207823 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
L897_RS06135 (L897_06310)	sepM	1208228..1209265 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
L897_RS06140 (L897_06315)	coaD	1209252..1209743 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
L897_RS06145 (L897_06320)	rsmD	1209733..1210272 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
L897_RS06150 (L897_06325)	asnA	1210395..1211387 (-)	993	WP_002994813.1	aspartate--ammonia ligase	-
L897_RS06155 (L897_06330)	arcC	1211753..1212703 (-)	951	WP_002994815.1	carbamate kinase	-
L897_RS06160 (L897_06335)	-	1212723..1214054 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=59939 L897_RS06135 WP_010922499.1 1208228..1209265(-) (sepM) [Streptococcus pyogenes HSC5]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=59939 L897_RS06135 WP_010922499.1 1208228..1209265(-) (sepM) [Streptococcus pyogenes HSC5]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693