Detailed information NTG0596135

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: K1X69_RS10020
• Genome accession: NZ_CP081354
• Coordinates: 2030336..2031379 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SQL1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2025336..2036379

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K1X69_RS09990 (K1X69_09990)	-	2025754..2027010 (-)	1257	WP_001795438.1	aminopeptidase	-
K1X69_RS09995 (K1X69_09995)	-	2027013..2027213 (-)	201	WP_000180461.1	DUF1128 family protein	-
K1X69_RS10000 (K1X69_10000)	-	2027360..2027824 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
K1X69_RS10005 (K1X69_10005)	-	2027831..2028106 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
K1X69_RS10010 (K1X69_10010)	-	2028384..2029601 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
K1X69_RS10015 (K1X69_10015)	vraR	2029717..2030346 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
K1X69_RS10020 (K1X69_10020)	vraS	2030336..2031379 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
K1X69_RS10025 (K1X69_10025)	liaF	2031376..2032077 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
K1X69_RS10030 (K1X69_10030)	-	2032092..2032478 (-)	387	WP_001110179.1	hypothetical protein	-
K1X69_RS10035 (K1X69_10035)	map	2032695..2033453 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
K1X69_RS10040 (K1X69_10040)	-	2033981..2034967 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
K1X69_RS10045 (K1X69_10045)	-	2035398..2035811 (-)	414	WP_001549145.1	hypothetical protein	-
K1X69_RS10050 (K1X69_10050)	-	2035840..2035950 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=596135 K1X69_RS10020 WP_001017131.1 2030336..2031379(-) (vraS) [Staphylococcus aureus strain SQL1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=596135 K1X69_RS10020 WP_001017131.1 2030336..2031379(-) (vraS) [Staphylococcus aureus strain SQL1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1