Detailed information NTG0593996

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JMO08_RS10465
• Genome accession: NZ_CP080562
• Coordinates: 2093137..2094180 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain HL21008
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2088137..2099180

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JMO08_RS10435 (JMO08_002087)	-	2088558..2089814 (-)	1257	WP_001795108.1	aminopeptidase	-
JMO08_RS10440 (JMO08_002088)	-	2089817..2090017 (-)	201	WP_000180460.1	DUF1128 family protein	-
JMO08_RS10445 (JMO08_002089)	-	2090164..2090628 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JMO08_RS10450 (JMO08_002090)	-	2090635..2090910 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
JMO08_RS10455 (JMO08_002091)	-	2091188..2092405 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
JMO08_RS10460 (JMO08_002092)	vraR	2092518..2093147 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
JMO08_RS10465 (JMO08_002093)	vraS	2093137..2094180 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JMO08_RS10470 (JMO08_002094)	liaF	2094177..2094878 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
JMO08_RS10475 (JMO08_002095)	-	2094893..2095279 (-)	387	WP_001110179.1	hypothetical protein	-
JMO08_RS10480 (JMO08_002096)	map	2095496..2096254 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
JMO08_RS10485 (JMO08_002097)	-	2096785..2097771 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
JMO08_RS10490 (JMO08_002098)	-	2098202..2098615 (-)	414	WP_001557448.1	hypothetical protein	-
JMO08_RS10495 (JMO08_002099)	-	2098644..2098754 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=593996 JMO08_RS10465 WP_001017131.1 2093137..2094180(-) (vraS) [Staphylococcus aureus strain HL21008]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=593996 JMO08_RS10465 WP_001017131.1 2093137..2094180(-) (vraS) [Staphylococcus aureus strain HL21008]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1