Detailed information NTG0593952

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JMO09_RS10750
• Genome accession: NZ_CP080560
• Coordinates: 2136533..2137576 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain HL17064
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2131533..2142576

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JMO09_RS10720 (JMO09_002144)	-	2131954..2133210 (-)	1257	WP_001795108.1	aminopeptidase	-
JMO09_RS10725 (JMO09_002145)	-	2133213..2133413 (-)	201	WP_000180460.1	DUF1128 family protein	-
JMO09_RS10730 (JMO09_002146)	-	2133560..2134024 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JMO09_RS10735 (JMO09_002147)	-	2134031..2134306 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
JMO09_RS10740 (JMO09_002148)	-	2134584..2135801 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
JMO09_RS10745 (JMO09_002149)	vraR	2135914..2136543 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
JMO09_RS10750 (JMO09_002150)	vraS	2136533..2137576 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JMO09_RS10755 (JMO09_002151)	liaF	2137573..2138274 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
JMO09_RS10760 (JMO09_002152)	-	2138289..2138675 (-)	387	WP_001110179.1	hypothetical protein	-
JMO09_RS10765 (JMO09_002153)	map	2138892..2139650 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
JMO09_RS10770 (JMO09_002154)	-	2140181..2141167 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
JMO09_RS10775 (JMO09_002155)	-	2141598..2142011 (-)	414	WP_001557448.1	hypothetical protein	-
JMO09_RS10780 (JMO09_002156)	-	2142040..2142150 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=593952 JMO09_RS10750 WP_001017131.1 2136533..2137576(-) (vraS) [Staphylococcus aureus strain HL17064]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=593952 JMO09_RS10750 WP_001017131.1 2136533..2137576(-) (vraS) [Staphylococcus aureus strain HL17064]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1