Detailed information NTG0593864

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JMO11_RS10340
• Genome accession: NZ_CP080553
• Coordinates: 2071452..2072495 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain HL18380
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2066452..2077495

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JMO11_RS10310 (JMO11_002060)	-	2066871..2068126 (-)	1256	Protein_1999	aminopeptidase	-
JMO11_RS10315 (JMO11_002061)	-	2068129..2068329 (-)	201	WP_000180461.1	DUF1128 family protein	-
JMO11_RS10320 (JMO11_002062)	-	2068476..2068940 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JMO11_RS10325 (JMO11_002063)	-	2068947..2069222 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
JMO11_RS10330 (JMO11_002064)	-	2069500..2070717 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
JMO11_RS10335 (JMO11_002065)	vraR	2070833..2071462 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
JMO11_RS10340 (JMO11_002066)	vraS	2071452..2072495 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JMO11_RS10345 (JMO11_002067)	liaF	2072492..2073193 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
JMO11_RS10350 (JMO11_002068)	-	2073208..2073594 (-)	387	WP_001110179.1	hypothetical protein	-
JMO11_RS10355 (JMO11_002069)	map	2073811..2074569 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
JMO11_RS10360 (JMO11_002070)	-	2075097..2076083 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
JMO11_RS10365 (JMO11_002071)	-	2076514..2076927 (-)	414	WP_001549145.1	hypothetical protein	-
JMO11_RS10370 (JMO11_002072)	-	2076956..2077066 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=593864 JMO11_RS10340 WP_001017131.1 2071452..2072495(-) (vraS) [Staphylococcus aureus strain HL18380]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=593864 JMO11_RS10340 WP_001017131.1 2071452..2072495(-) (vraS) [Staphylococcus aureus strain HL18380]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1