Detailed information NTG0593734

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JMO14_RS10470
• Genome accession: NZ_CP080550
• Coordinates: 2093770..2094813 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain HL18883
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2088770..2099813

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JMO14_RS10440 (JMO14_002089)	-	2089191..2090447 (-)	1257	WP_001795108.1	aminopeptidase	-
JMO14_RS10445 (JMO14_002090)	-	2090450..2090650 (-)	201	WP_000180460.1	DUF1128 family protein	-
JMO14_RS10450 (JMO14_002091)	-	2090797..2091261 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JMO14_RS10455 (JMO14_002092)	-	2091268..2091543 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
JMO14_RS10460 (JMO14_002093)	-	2091821..2093038 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
JMO14_RS10465 (JMO14_002094)	vraR	2093151..2093780 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
JMO14_RS10470 (JMO14_002095)	vraS	2093770..2094813 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JMO14_RS10475 (JMO14_002096)	liaF	2094810..2095511 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
JMO14_RS10480 (JMO14_002097)	-	2095526..2095912 (-)	387	WP_001110179.1	hypothetical protein	-
JMO14_RS10485 (JMO14_002098)	map	2096129..2096887 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
JMO14_RS10490 (JMO14_002099)	-	2097418..2098404 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
JMO14_RS10495 (JMO14_002100)	-	2098835..2099248 (-)	414	WP_001557448.1	hypothetical protein	-
JMO14_RS10500 (JMO14_002101)	-	2099277..2099387 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=593734 JMO14_RS10470 WP_001017131.1 2093770..2094813(-) (vraS) [Staphylococcus aureus strain HL18883]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=593734 JMO14_RS10470 WP_001017131.1 2093770..2094813(-) (vraS) [Staphylococcus aureus strain HL18883]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1