Detailed information NTG0059293

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: CA347_RS00290
• Genome accession: NC_021554
• Coordinates: 64039..65388 (-)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus CA-347
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	44020..65388	64039..65388	within	0

Gene organization within MGE regions

Location: 44020..65388

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CA347_RS00190 (CA347_39)	mecA	44020..46029 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
CA347_RS00195 (CA347_40)	mecR1	46126..47883 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
CA347_RS00200 (CA347_41)	mecI	47883..48254 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
CA347_RS15355	psm-mec	48339..48407 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
CA347_RS00205 (CA347_42)	-	48741..49871 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
CA347_RS00215 (CA347_44)	cstB	49985..51319 (-)	1335	Protein_39	persulfide dioxygenase-sulfurtransferase CstB	-
CA347_RS00220 (CA347_45)	-	51352..52416 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
CA347_RS00225 (CA347_46)	cstR	52552..52812 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
CA347_RS00230	-	52812..53450 (+)	639	Protein_42	sulfite exporter TauE/SafE family protein	-
CA347_RS00235 (CA347_48)	-	53795..54457 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
CA347_RS15760	-	54849..54908 (+)	60	WP_010959190.1	erythromycin resistance leader peptide	-
CA347_RS00240 (CA347_49)	erm(A)	54991..55722 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
CA347_RS00245 (CA347_50)	-	55848..56630 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
CA347_RS00250 (CA347_51)	-	56781..57158 (-)	378	WP_000361059.1	DUF6262 family protein	-
CA347_RS00255 (CA347_52)	-	57165..59057 (-)	1893	WP_001557544.1	site-specific integrase	-
CA347_RS00260 (CA347_53)	-	59054..60139 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
CA347_RS00265 (CA347_54)	-	60258..60575 (-)	318	WP_000659050.1	JAB domain-containing protein	-
CA347_RS00270 (CA347_55)	-	60596..61102 (-)	507	WP_001092169.1	DUF1643 domain-containing protein	-
CA347_RS00275 (CA347_56)	-	61120..61431 (-)	312	WP_000700853.1	DUF960 family protein	-
CA347_RS00280 (CA347_57)	-	61518..61868 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
CA347_RS00285 (CA347_58)	ccrB	62386..64017 (-)	1632	WP_016528665.1	cassette chromosome recombinase CcrB	Machinery gene
CA347_RS00290 (CA347_59)	ccrA	64039..65388 (-)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=59293 CA347_RS00290 WP_000815646.1 64039..65388(-) (ccrA) [Staphylococcus aureus CA-347]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=59293 CA347_RS00290 WP_000815646.1 64039..65388(-) (ccrA) [Staphylococcus aureus CA-347]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748