Detailed information NTG0591727

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KZZ50_RS09630
• Genome accession: NZ_CP080251
• Coordinates: 1955258..1956301 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NT_611
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1950258..1961301

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KZZ50_RS09600 (KZZ50_09575)	-	1950680..1951936 (-)	1257	WP_217654526.1	aminopeptidase	-
KZZ50_RS09605 (KZZ50_09580)	-	1951939..1952139 (-)	201	WP_000180460.1	DUF1128 family protein	-
KZZ50_RS09610 (KZZ50_09585)	-	1952286..1952750 (+)	465	WP_000567539.1	low molecular weight protein-tyrosine-phosphatase	-
KZZ50_RS09615 (KZZ50_09590)	-	1952757..1953032 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KZZ50_RS09620 (KZZ50_09595)	-	1953310..1954527 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
KZZ50_RS09625 (KZZ50_09600)	vraR	1954639..1955268 (-)	630	WP_000153532.1	two-component system response regulator VraR	Regulator
KZZ50_RS09630 (KZZ50_09605)	vraS	1955258..1956301 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KZZ50_RS09635 (KZZ50_09610)	liaF	1956298..1956999 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KZZ50_RS09640 (KZZ50_09615)	-	1957014..1957400 (-)	387	WP_001110179.1	hypothetical protein	-
KZZ50_RS09645 (KZZ50_09620)	map	1957617..1958375 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KZZ50_RS09650 (KZZ50_09625)	-	1958847..1959833 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
KZZ50_RS09655 (KZZ50_09630)	-	1960264..1960677 (-)	414	WP_025175030.1	hypothetical protein	-
KZZ50_RS09660 (KZZ50_09635)	-	1960706..1960816 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=591727 KZZ50_RS09630 WP_001017131.1 1955258..1956301(-) (vraS) [Staphylococcus aureus strain NT_611]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=591727 KZZ50_RS09630 WP_001017131.1 1955258..1956301(-) (vraS) [Staphylococcus aureus strain NT_611]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTGAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1