Detailed information NTG0590193

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: KZH43_RS08790
• Genome accession: NZ_CP079923
• Coordinates: 1747982..1749019 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain Rx1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1742982..1754019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KZH43_RS08765 (KZH43_08760)	-	1743783..1745114 (-)	1332	WP_000390046.1	hemolysin family protein	-
KZH43_RS08770 (KZH43_08765)	endA	1745343..1746167 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
KZH43_RS08775 (KZH43_08770)	-	1746206..1746394 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
KZH43_RS08780 (KZH43_08775)	murA	1746387..1747670 (-)	1284	WP_000358027.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
KZH43_RS08785 (KZH43_08780)	-	1747694..1747924 (-)	231	WP_000250384.1	DUF1146 family protein	-
KZH43_RS08790 (KZH43_08785)	sepM	1747982..1749019 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
KZH43_RS08795 (KZH43_08790)	coaD	1749003..1749491 (-)	489	WP_001280727.1	pantetheine-phosphate adenylyltransferase	-
KZH43_RS08800 (KZH43_08795)	rsmD	1749481..1750020 (-)	540	WP_000706962.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
KZH43_RS08805 (KZH43_08800)	asnA	1750085..1751077 (-)	993	WP_000747995.1	aspartate--ammonia ligase	-
KZH43_RS08810 (KZH43_08805)	-	1751189..1751872 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
KZH43_RS08815 (KZH43_08810)	-	1751928..1752668 (-)	741	WP_000152673.1	RNA methyltransferase	-
KZH43_RS08820 (KZH43_08815)	-	1752702..1752980 (+)	279	WP_001174613.1	acylphosphatase	-
KZH43_RS08825 (KZH43_08820)	yidC	1753058..1753984 (+)	927	WP_000835947.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=590193 KZH43_RS08790 WP_000727277.1 1747982..1749019(-) (sepM) [Streptococcus pneumoniae strain Rx1]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=590193 KZH43_RS08790 WP_000727277.1 1747982..1749019(-) (sepM) [Streptococcus pneumoniae strain Rx1]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGCATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591