Detailed information NTG0587598

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KWH15_RS09415
• Genome accession: NZ_CP078521
• Coordinates: 1923984..1925027 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ATCC 29213
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1918984..1930027

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KWH15_RS09385 (KWH15_09385)	-	1919405..1920661 (-)	1257	WP_001795108.1	aminopeptidase	-
KWH15_RS09390 (KWH15_09390)	-	1920664..1920864 (-)	201	WP_000180460.1	DUF1128 family protein	-
KWH15_RS09395 (KWH15_09395)	-	1921011..1921475 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KWH15_RS09400 (KWH15_09400)	-	1921482..1921757 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KWH15_RS09405 (KWH15_09405)	-	1922035..1923252 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KWH15_RS09410 (KWH15_09410)	vraR	1923365..1923994 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KWH15_RS09415 (KWH15_09415)	vraS	1923984..1925027 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KWH15_RS09420 (KWH15_09420)	liaF	1925024..1925725 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KWH15_RS09425 (KWH15_09425)	-	1925740..1926126 (-)	387	WP_001110179.1	hypothetical protein	-
KWH15_RS09430 (KWH15_09430)	map	1926343..1927101 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KWH15_RS09435 (KWH15_09435)	-	1927632..1928618 (+)	987	WP_031768943.1	aromatic acid exporter family protein	-
KWH15_RS09440 (KWH15_09440)	-	1929049..1929462 (-)	414	WP_001557448.1	hypothetical protein	-
KWH15_RS09445 (KWH15_09445)	-	1929491..1929601 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=587598 KWH15_RS09415 WP_001017131.1 1923984..1925027(-) (vraS) [Staphylococcus aureus strain ATCC 29213]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=587598 KWH15_RS09415 WP_001017131.1 1923984..1925027(-) (vraS) [Staphylococcus aureus strain ATCC 29213]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1