Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   K750_RS03040 Genome accession   NC_021217
Coordinates   630318..632102 (+) Length   594 a.a.
NCBI ID   WP_015644212.1    Uniprot ID   A0AB33Z8E6
Organism   Helicobacter pylori UM037     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 625318..637102
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K750_RS03010 (K750_04860) motB 626082..626855 (+) 774 WP_001085335.1 flagellar motor protein MotB -
  K750_RS03015 (K750_04855) - 626861..627298 (+) 438 WP_031245451.1 hypothetical protein -
  K750_RS03020 (K750_04850) - 627367..629028 (+) 1662 WP_015644215.1 ABC transporter permease/substrate-binding protein -
  K750_RS03025 (K750_04845) - 629032..629682 (+) 651 WP_015644214.1 ATP-binding cassette domain-containing protein -
  K750_RS03030 (K750_09880) - 629685..629864 (-) 180 WP_000468793.1 hypothetical protein -
  K750_RS03035 (K750_04835) - 629856..630317 (+) 462 WP_015644213.1 hypothetical protein -
  K750_RS03040 (K750_04830) uvrC 630318..632102 (+) 1785 WP_015644212.1 excinuclease ABC subunit UvrC Machinery gene
  K750_RS03045 (K750_04825) - 632113..633378 (+) 1266 WP_015644211.1 homoserine dehydrogenase -
  K750_RS03050 (K750_04820) - 633379..633723 (+) 345 WP_001211718.1 YraN family protein -
  K750_RS03055 (K750_04815) trxA 633812..634132 (+) 321 WP_000020199.1 thioredoxin -
  K750_RS03060 (K750_04810) trxB 634137..635072 (+) 936 WP_015644210.1 thioredoxin-disulfide reductase -
  K750_RS03065 (K750_04805) - 635445..636266 (+) 822 WP_015644209.1 glycosyltransferase family 25 protein -
  K750_RS03070 (K750_04800) - 636489..636737 (-) 249 WP_000790557.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68660.85 Da        Isoelectric Point: 9.6703

>NTDB_id=58712 K750_RS03040 WP_015644212.1 630318..632102(+) (uvrC) [Helicobacter pylori UM037]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLS
ACSNEVLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDRILEEVRSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEAIAISKEKRDSKAYRSKGGAKDIIHTPNNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKDMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=58712 K750_RS03040 WP_015644212.1 630318..632102(+) (uvrC) [Helicobacter pylori UM037]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
GCTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATTACGCCCA
ACCATCGTGCAAGCTTACGAATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAATGAGCAA
GACGCTTTGATTTTAGAAAACTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCATTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAGCTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGTATGGATTTAGCCAAACTCTACGATTTGGATATTTTCGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CCGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATACCAGAACAGATCTTATTGAGC
GCTTGCTCTAATGAAGTGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAGGAAAAAACCTCTA
ATGAAGATCGGATTTTAGAAGAAGTGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAATGCATTTCAAAAAAACTCTTATCGGCG
TTACCATTTAAAAGGCTCTAACGAATACGATCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATAGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGCGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAACAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAGACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.97

100

0.97

Multiple sequence alignment