Detailed information NTG0058650

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: TL13_RS10030
• Genome accession: NC_021213
• Coordinates: 2035923..2037119 (+)
• Length: 398 a.a.
• NCBI ID: WP_009911075.1
• Uniprot ID: G7SHV4
• Organism: Streptococcus suis TL13
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2030923..2042119

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
TL13_RS09985 (TL13_1997)	-	2031617..2032258 (+)	642	WP_015647600.1	replication protein	-
TL13_RS09990 (TL13_1998)	-	2032264..2032548 (+)	285	WP_015647601.1	hypothetical protein	-
TL13_RS09995 (TL13_1999)	-	2032541..2032873 (+)	333	WP_015647602.1	DUF771 domain-containing protein	-
TL13_RS10000 (TL13_2000)	-	2032936..2034057 (+)	1122	WP_014638877.1	site-specific integrase	-
TL13_RS10020 (TL13_2004)	-	2034562..2035245 (-)	684	WP_015647603.1	YoaK family protein	-
TL13_RS10025 (TL13_2005)	rlmH	2035270..2035749 (-)	480	WP_015647604.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
TL13_RS10030 (TL13_2006)	htrA	2035923..2037119 (+)	1197	WP_009911075.1	S1C family serine protease	Regulator
TL13_RS10035 (TL13_2007)	spo0J	2037180..2037944 (+)	765	WP_012775418.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41818.83 Da
• Isoelectric Point: 4.6655

>NTDB_id=58650 TL13_RS10030 WP_009911075.1 2035923..2037119(+) (htrA) [Streptococcus suis TL13]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPRVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSKDGQTISTNAIQTDTAINPGNSGGPLIN
TQGQVIGITSSKITSSSANSSGVAVEGLGFAIPANDAVAIINQLEKTGQVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=58650 TL13_RS10030 WP_009911075.1 2035923..2037119(+) (htrA) [Streptococcus suis TL13]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAGCCACGGGTTCAACAAGCAAATTCTGCCATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCTACTACAAAGGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAGTCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCCGTTGCTGGGGAGGGATCTGGTGTTAT
CTACAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATCCTTT
TAGCATCTGGAGAAAAAATTAGCGGTGAACTTGTTGGTTCTGATACATATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCCAATACAGTTACCCAGGGTATTATTTCTAGCTTAAGCCGGACAGTTACTTCACAATCAAAAG
ATGGACAAACAATCTCAACCAACGCTATTCAAACTGATACAGCTATCAACCCTGGAAACTCTGGCGGACCGTTAATCAAT
ACCCAAGGACAAGTGATAGGCATTACCTCTAGCAAAATTACCTCAAGTTCTGCAAATAGCTCAGGCGTGGCTGTAGAAGG
GTTGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAGCTTGAAAAAACTGGACAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGACTACCTGCAGATGGAAAATTAGAAACTTTTGATGTCATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAAAGCGCTCTCTACAAACATCAAATTGGTGACACAATCACTG
TAACCTACTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (293-389)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: G7SHV4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	59.446	99.749	0.593
htrA	Streptococcus gordonii str. Challis substr. CH1	59.494	99.246	0.59
htrA	Streptococcus pneumoniae D39	57.252	98.744	0.565
htrA	Streptococcus pneumoniae TIGR4	57.252	98.744	0.565
htrA	Streptococcus mitis NCTC 12261	57.252	98.744	0.565
htrA	Streptococcus pneumoniae R6	57.252	98.744	0.565
htrA	Streptococcus pneumoniae Rx1	57.252	98.744	0.565