Detailed information NTG0585478

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU526_RS12795
• Genome accession: NZ_CP077931
• Coordinates: 2616539..2617582 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 195
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2611539..2622582

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU526_RS12765 (KU526_12725)	-	2612162..2612271 (+)	110	Protein_2525	hypothetical protein	-
KU526_RS12770 (KU526_12730)	-	2612300..2612713 (+)	414	WP_001622129.1	hypothetical protein	-
KU526_RS12775 (KU526_12735)	-	2612891..2613877 (-)	987	WP_000999713.1	FUSC family protein	-
KU526_RS12780 (KU526_12740)	map	2614465..2615223 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
KU526_RS12785 (KU526_12745)	-	2615440..2615826 (+)	387	WP_001110184.1	hypothetical protein	-
KU526_RS12790 (KU526_12750)	liaF	2615841..2616542 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU526_RS12795 (KU526_12755)	vraS	2616539..2617582 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU526_RS12800 (KU526_12760)	vraR	2617572..2618201 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU526_RS12805 (KU526_12765)	-	2618314..2619531 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU526_RS12810 (KU526_12770)	-	2619809..2620084 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU526_RS12815 (KU526_12775)	-	2620091..2620555 (-)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
KU526_RS12820 (KU526_12780)	-	2620702..2620902 (+)	201	WP_000180459.1	DUF1128 family protein	-
KU526_RS12825 (KU526_12785)	-	2620914..2622161 (+)	1248	WP_000656302.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585478 KU526_RS12795 WP_001017131.1 2616539..2617582(+) (vraS) [Staphylococcus aureus strain 195]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585478 KU526_RS12795 WP_001017131.1 2616539..2617582(+) (vraS) [Staphylococcus aureus strain 195]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1