Detailed information NTG0585401

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU511_RS01695
• Genome accession: NZ_CP077928
• Coordinates: 320058..321101 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 196
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 315058..326101

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU511_RS01665 (KU511_01665)	-	315681..315790 (+)	110	Protein_319	hypothetical protein	-
KU511_RS01670 (KU511_01670)	-	315819..316232 (+)	414	WP_001622129.1	hypothetical protein	-
KU511_RS01675 (KU511_01675)	-	316410..317396 (-)	987	WP_000999713.1	FUSC family protein	-
KU511_RS01680 (KU511_01680)	map	317984..318742 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
KU511_RS01685 (KU511_01685)	-	318959..319345 (+)	387	WP_001110184.1	hypothetical protein	-
KU511_RS01690 (KU511_01690)	liaF	319360..320061 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU511_RS01695 (KU511_01695)	vraS	320058..321101 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU511_RS01700 (KU511_01700)	vraR	321091..321720 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU511_RS01705 (KU511_01705)	-	321833..323050 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU511_RS01710 (KU511_01710)	-	323328..323603 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU511_RS01715 (KU511_01715)	-	323610..324074 (-)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
KU511_RS01720 (KU511_01720)	-	324221..324421 (+)	201	WP_000180459.1	DUF1128 family protein	-
KU511_RS01725 (KU511_01725)	-	324490..325680 (+)	1191	WP_411896787.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585401 KU511_RS01695 WP_001017131.1 320058..321101(+) (vraS) [Staphylococcus aureus strain 196]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585401 KU511_RS01695 WP_001017131.1 320058..321101(+) (vraS) [Staphylococcus aureus strain 196]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1