Detailed information NTG0585367

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU504_RS06735
• Genome accession: NZ_CP077926
• Coordinates: 1383383..1384426 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 197
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1378383..1389426

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU504_RS06705 (KU504_06680)	-	1379006..1379115 (+)	110	Protein_1313	hypothetical protein	-
KU504_RS06710 (KU504_06685)	-	1379144..1379557 (+)	414	WP_001622129.1	hypothetical protein	-
KU504_RS06715 (KU504_06690)	-	1379735..1380721 (-)	987	WP_000999713.1	FUSC family protein	-
KU504_RS06720 (KU504_06695)	map	1381309..1382067 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
KU504_RS06725 (KU504_06700)	-	1382284..1382670 (+)	387	WP_001110184.1	hypothetical protein	-
KU504_RS06730 (KU504_06705)	liaF	1382685..1383386 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU504_RS06735 (KU504_06710)	vraS	1383383..1384426 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU504_RS06740 (KU504_06715)	vraR	1384416..1385045 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU504_RS06745 (KU504_06720)	-	1385158..1386375 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU504_RS06750 (KU504_06725)	-	1386653..1386928 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU504_RS06755 (KU504_06730)	-	1386935..1387399 (-)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
KU504_RS06760 (KU504_06735)	-	1387546..1387746 (+)	201	WP_000180459.1	DUF1128 family protein	-
KU504_RS06765 (KU504_06740)	-	1387815..1389005 (+)	1191	WP_411896787.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585367 KU504_RS06735 WP_001017131.1 1383383..1384426(+) (vraS) [Staphylococcus aureus strain 197]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585367 KU504_RS06735 WP_001017131.1 1383383..1384426(+) (vraS) [Staphylococcus aureus strain 197]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1