Detailed information NTG0585350

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU531_RS10025
• Genome accession: NZ_CP077925
• Coordinates: 2042728..2043771 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 198
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2037728..2048771

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU531_RS09995 (KU531_09955)	-	2038149..2039339 (-)	1191	WP_411896787.1	aminopeptidase	-
KU531_RS10000 (KU531_09960)	-	2039408..2039608 (-)	201	WP_000180459.1	DUF1128 family protein	-
KU531_RS10005 (KU531_09965)	-	2039755..2040219 (+)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
KU531_RS10010 (KU531_09970)	-	2040226..2040501 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU531_RS10015 (KU531_09975)	-	2040779..2041996 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
KU531_RS10020 (KU531_09980)	vraR	2042109..2042738 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU531_RS10025 (KU531_09985)	vraS	2042728..2043771 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU531_RS10030 (KU531_09990)	liaF	2043768..2044469 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU531_RS10035 (KU531_09995)	-	2044484..2044870 (-)	387	WP_001110184.1	hypothetical protein	-
KU531_RS10040 (KU531_10000)	map	2045087..2045845 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
KU531_RS10045 (KU531_10005)	-	2046433..2047419 (+)	987	WP_000999713.1	FUSC family protein	-
KU531_RS10050 (KU531_10010)	-	2047597..2048010 (-)	414	WP_001622129.1	hypothetical protein	-
KU531_RS10055 (KU531_10015)	-	2048039..2048148 (-)	110	Protein_1951	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585350 KU531_RS10025 WP_001017131.1 2042728..2043771(-) (vraS) [Staphylococcus aureus strain 198]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585350 KU531_RS10025 WP_001017131.1 2042728..2043771(-) (vraS) [Staphylococcus aureus strain 198]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1