Detailed information NTG0585235

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU534_RS03705
• Genome accession: NZ_CP077923
• Coordinates: 702232..703275 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 201
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 697232..708275

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU534_RS03675 (KU534_03645)	-	697957..698067 (+)	111	WP_014937049.1	hypothetical protein	-
KU534_RS03680 (KU534_03650)	-	698096..698509 (+)	414	WP_025174370.1	hypothetical protein	-
KU534_RS03685 (KU534_03655)	-	698698..699684 (-)	987	WP_000999712.1	FUSC family protein	-
KU534_RS03690 (KU534_03660)	map	700158..700916 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
KU534_RS03695 (KU534_03665)	-	701133..701519 (+)	387	WP_001110182.1	hypothetical protein	-
KU534_RS03700 (KU534_03670)	liaF	701534..702235 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU534_RS03705 (KU534_03675)	vraS	702232..703275 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU534_RS03710 (KU534_03680)	vraR	703265..703894 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU534_RS03715 (KU534_03685)	-	704007..705224 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
KU534_RS03720 (KU534_03690)	-	705502..705777 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KU534_RS03725 (KU534_03695)	-	705784..706248 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU534_RS03730 (KU534_03700)	-	706395..706595 (+)	201	WP_000180460.1	DUF1128 family protein	-
KU534_RS03735 (KU534_03705)	-	706598..707854 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585235 KU534_RS03705 WP_001017131.1 702232..703275(+) (vraS) [Staphylococcus aureus strain 201]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585235 KU534_RS03705 WP_001017131.1 702232..703275(+) (vraS) [Staphylococcus aureus strain 201]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1