Detailed information NTG0585216

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU538_RS06455
• Genome accession: NZ_CP077922
• Coordinates: 1315967..1317010 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 202
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1310967..1322010

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU538_RS06425 (KU538_06385)	-	1311388..1312644 (-)	1257	WP_001793428.1	aminopeptidase	-
KU538_RS06430 (KU538_06390)	-	1312647..1312847 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU538_RS06435 (KU538_06395)	-	1312994..1313458 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU538_RS06440 (KU538_06400)	-	1313465..1313740 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU538_RS06445 (KU538_06405)	-	1314018..1315235 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
KU538_RS06450 (KU538_06410)	vraR	1315348..1315977 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU538_RS06455 (KU538_06415)	vraS	1315967..1317010 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU538_RS06460 (KU538_06420)	liaF	1317007..1317708 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU538_RS06465 (KU538_06425)	-	1317723..1318109 (-)	387	WP_001110182.1	hypothetical protein	-
KU538_RS06470 (KU538_06430)	map	1318326..1319084 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
KU538_RS06475 (KU538_06435)	-	1319558..1320544 (+)	987	WP_000999712.1	FUSC family protein	-
KU538_RS06480 (KU538_06440)	-	1320733..1321146 (-)	414	WP_025174370.1	hypothetical protein	-
KU538_RS06485 (KU538_06445)	-	1321175..1321285 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585216 KU538_RS06455 WP_001017131.1 1315967..1317010(-) (vraS) [Staphylococcus aureus strain 202]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585216 KU538_RS06455 WP_001017131.1 1315967..1317010(-) (vraS) [Staphylococcus aureus strain 202]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1